中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

文献类型:期刊论文

AuthorLi, Mengqi1; Zhang, Chen-Song1; Zong, Yue1; Feng, Jin-Wei1; Ma, Teng1; Hu, Meiqin2; Lin, Zhizhong1; Li, Xiaotong1; Xie, Changchuan1; Wu, Yaying1
SourceCELL METABOLISM
Issued Date2019-09-03
Volume30Issue:3Pages:508-+
ISSN1550-4131
DOI10.1016/j.cmet.2019.05.018
Corresponding AuthorLin, Sheng-Cai(linsc@xmu.edu.cn)
English AbstractFructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of calcium at contact sites between ER and lysosome renders the inhibited TRPV accessible to bind the lysosomal v-ATPase that then recruits AXIN:LKB1 to activate AMPK independently of AMP. Genetic depletion of TRPVs blocks glucose starvation-induced AMPK activation in cells and liver of mice, and in nematodes, indicative of physical requirement of TRPVs. Pharmacological inhibition of TRPVs activates AMPK and elevates NAD(+) levels in aged muscles, rejuvenating the animals' running capacity. Our study elucidates that TRPVs relay the FBP-free status of aldolase to the reconfiguration of v-ATPase, leading to AMPK activation in low glucose.
WOS KeywordACTIVATED PROTEIN-KINASE ; COMMON ACTIVATOR ; ION-CHANNEL ; LIFE-SPAN ; MITOCHONDRIAL ; ATPASE ; METABOLISM ; MECHANISM ; CALCIUM ; CELLS
Funding ProjectNational Natural Science Foundation of China[31730058] ; National Natural Science Foundation of China[31430094] ; National Natural Science Foundation of China[31601152] ; National Natural Science Foundation of China[31690101] ; National Key R&D Program of China[2016YFA0502001] ; Wellcome Trust[204766/Z/16/Z]
WOS Research AreaCell Biology ; Endocrinology & Metabolism
Language英语
WOS IDWOS:000484370400012
PublisherCELL PRESS
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173009]  
Collection大连化学物理研究所_中国科学院大连化学物理研究所
Corresponding AuthorLin, Sheng-Cai
Affiliation1.Xiamen Univ, Innovat Ctr Cell Signaling Network, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China
2.Peking Univ, Inst Mol Med, PKU IDG McGovern Inst Brain Res, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
3.Tsinghua Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
6.Univ Texas Southwestern Med Ctr Dallas, McDermott Ctr Human Growth & Dev MC8591, Dallas, TX 75390 USA
7.Univ Dundee, Coll Life Sci, Div Cell Signalling & Immunol, Dundee DD1 5EH, Scotland
Recommended Citation
GB/T 7714
Li, Mengqi,Zhang, Chen-Song,Zong, Yue,et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK[J]. CELL METABOLISM,2019,30(3):508-+.
APA Li, Mengqi.,Zhang, Chen-Song.,Zong, Yue.,Feng, Jin-Wei.,Ma, Teng.,...&Lin, Sheng-Cai.(2019).Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.CELL METABOLISM,30(3),508-+.
MLA Li, Mengqi,et al."Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK".CELL METABOLISM 30.3(2019):508-+.

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来源:大连化学物理研究所

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