中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 大连化学物理研究所
  3. 中国科学院大连化学物理研究所
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

文献类型：期刊论文

作者Li, Mengqi1; Zhang, Chen-Song1; Zong, Yue1; Feng, Jin-Wei1; Ma, Teng1; Hu, Meiqin2; Lin, Zhizhong1; Li, Xiaotong1; Xie, Changchuan1; Wu, Yaying1
刊名CELL METABOLISM
出版日期2019-09-03
卷号30期号:3页码:508-+
ISSN号1550-4131
DOI10.1016/j.cmet.2019.05.018
通讯作者Lin, Sheng-Cai(linsc@xmu.edu.cn)
英文摘要Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease of calcium at contact sites between ER and lysosome renders the inhibited TRPV accessible to bind the lysosomal v-ATPase that then recruits AXIN:LKB1 to activate AMPK independently of AMP. Genetic depletion of TRPVs blocks glucose starvation-induced AMPK activation in cells and liver of mice, and in nematodes, indicative of physical requirement of TRPVs. Pharmacological inhibition of TRPVs activates AMPK and elevates NAD(+) levels in aged muscles, rejuvenating the animals' running capacity. Our study elucidates that TRPVs relay the FBP-free status of aldolase to the reconfiguration of v-ATPase, leading to AMPK activation in low glucose.
WOS关键词ACTIVATED PROTEIN-KINASE ; COMMON ACTIVATOR ; ION-CHANNEL ; LIFE-SPAN ; MITOCHONDRIAL ; ATPASE ; METABOLISM ; MECHANISM ; CALCIUM ; CELLS
资助项目National Natural Science Foundation of China[31730058] ; National Natural Science Foundation of China[31430094] ; National Natural Science Foundation of China[31601152] ; National Natural Science Foundation of China[31690101] ; National Key R&D Program of China[2016YFA0502001] ; Wellcome Trust[204766/Z/16/Z]
WOS研究方向Cell Biology ; Endocrinology & Metabolism
语种英语
出版者CELL PRESS
WOS记录号WOS:000484370400012
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; Wellcome Trust ; Wellcome Trust
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173009]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Lin, Sheng-Cai
作者单位1.Xiamen Univ, Innovat Ctr Cell Signaling Network, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China
2.Peking Univ, Inst Mol Med, PKU IDG McGovern Inst Brain Res, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
3.Tsinghua Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Inst Mol Med, State Key Lab Membrane Biol, Beijing 100871, Peoples R China
6.Univ Texas Southwestern Med Ctr Dallas, McDermott Ctr Human Growth & Dev MC8591, Dallas, TX 75390 USA
7.Univ Dundee, Coll Life Sci, Div Cell Signalling & Immunol, Dundee DD1 5EH, Scotland
推荐引用方式
GB/T 7714		 Li, Mengqi,Zhang, Chen-Song,Zong, Yue,et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK[J]. CELL METABOLISM,2019,30(3):508-+.
APA Li, Mengqi.,Zhang, Chen-Song.,Zong, Yue.,Feng, Jin-Wei.,Ma, Teng.,...&Lin, Sheng-Cai.(2019).Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.CELL METABOLISM,30(3),508-+.
MLA Li, Mengqi,et al."Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK".CELL METABOLISM 30.3(2019):508-+.

入库方式： OAI收割

来源：大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。