Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets
文献类型：期刊论文
| 作者 | Feng, Jie1; Gao, Hua1; Zhang, Qi2,7; Zhou, Yang3,8; Li, Chuzhong1; Zhao, Sida1; Hong, Lichuan1; Yang, Jinjin1; Hao, Shuyu4; Hong, Wan1 |
| 刊名 | JOURNAL OF TRANSLATIONAL MEDICINE
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| 出版日期 | 2019-08-28 |
| 卷号 | 17期号:1页码:13 |
| 关键词 | Proteomics Metabolomics Microarray Pituitary adenomas Metabolites |
| DOI | 10.1186/s12967-019-2042-9 |
| 通讯作者 | Xu, Guowang(xugw@dicp.ac.cn) ; Zhang, Yazhuo(zyz2004520@yeah.net) |
| 英文摘要 | BackgroundPituitary adenomas are common brain tumors. Although transsphenoidal surgery are able to achieve extensive tumor removal, the rate of recurrence ranges from 5 to 20% depending on the different subtype. Further understanding of these tumors is needed to develop novel strategies to improve the prognosis of patients. But their metabolic characteristics are largely unknown.MethodsWe used metabolomic, transcriptomic, and proteomic approaches to systematically investigate eight subtypes of pituitary adenomas and normal pituitary glands. By blocking IDH2, we investigate IDH2 play an inhibitory role in GH tumor cell growth and tumor secretion.ResultsWe found that all of the pituitary adenomas displayed downregulated glucose metabolism and glycolysis compared to normal tissues. Together with the differences in amino acids and fatty acids, we categorized these tumors into three clusters. We then re-established the reprogrammed metabolic flux in pituitary adenomas based on multiomic analyses. Take growth hormone-secreting pituitary adenomas as an example, we revealed that IDH2 is a key player in the reprogrammed metabolism of such tumors. By blocking IDH2, we confirmed that IDH2 is a potential target for the inhibition of tumor cell growth and tumor secretion.ConclusionsOur study first uncovered the metabolic landscape of pituitary adenomas and demonstrated a possible way to inhibit tumor growth by regulating aberrant metabolism. |
| WOS关键词 | NULL-CELL ADENOMAS ; ONCOCYTOMAS ; DIAGNOSIS |
| 资助项目 | National Natural Science Foundation of China[81702455] ; Research Special Fund for Public Welfare Industry of Health[201402008] ; National High Technology Research and Development Program of China[2014AA020610] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000483363300002 |
| 出版者 | BMC |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Research Special Fund for Public Welfare Industry of Health ; National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Research Special Fund for Public Welfare Industry of Health ; National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Research Special Fund for Public Welfare Industry of Health ; National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Research Special Fund for Public Welfare Industry of Health ; National High Technology Research and Development Program of China ; National High Technology Research and Development Program of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/173145]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang; Zhang, Yazhuo |
| 作者单位 | 1.Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China 2.NCI, Neurooncol Branch, NIH, Bethesda, MD 20852 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China 5.Capital Med Univ, Beijing Inst Brain Disorders, Brain Tumor Ctr, Beijing 100050, Peoples R China 6.China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China 7.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310009, Zhejiang, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Jie,Gao, Hua,Zhang, Qi,et al. Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2019,17(1):13. |
| APA | Feng, Jie.,Gao, Hua.,Zhang, Qi.,Zhou, Yang.,Li, Chuzhong.,...&Zhang, Yazhuo.(2019).Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets.JOURNAL OF TRANSLATIONAL MEDICINE,17(1),13. |
| MLA | Feng, Jie,et al."Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets".JOURNAL OF TRANSLATIONAL MEDICINE 17.1(2019):13. |
入库方式： OAI收割
来源：大连化学物理研究所
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