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Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells

文献类型：期刊论文

作者Jia, Chao1; Zhang, Man2; Zhang, Yan3; Ma, Zi-Bo1; Xiao, Nan-Nan3; He, Xi-Wen1; Li, Wen-You1,4; Zhang, Yu-Kui1,5
刊名ACS APPLIED MATERIALS & INTERFACES
出版日期2019-09-04
卷号11期号:35页码:32431-32440
ISSN号1944-8244
关键词molecular imprinting drug delivery in vivo target imaging
DOI10.1021/acsami.9b11533
通讯作者Li, Wen-You(wyli@nankai.edu.cn) ; Zhang, Yu-Kui(ykzhang@dicp.ac.cn)
英文摘要Molecularly imprinted polymers were commonly used for drug delivery. However, single-template molecularly imprinted polymers often fail to achieve both drug delivery and precise targeting. To address this issue, a dual-template molecularly imprinted polymer nanoparticle used for targeted diagnosis and drug delivery for pancreatic cancer BxPC-3 cells (FH-MIPNPs) was prepared. In the FH-MIPNPs, the 71-80 peptide of human fibroblast growthfactor-inducible 14 modified with glucose (Glu-FH) and bleomycin (BLM) were used as templates simultaneously, so that the FH-MIPNPs could load BLM and bind to the BxPC3 cells, which overexpress human fibroblast growth-factorinducible 14 (FN14). Targeted imaging experiments in vitro show that the FH-MIPNPs could specifically target BxPC-3 cells and that there is no targeting effect on cells without expression of FN14. In vivo antitumor experiment results demonstrated that the FH-MIPNP-loaded BLM (FH-MIPNPs/BLM) could inhibit the growth of xenografts tumor of BxPC-3 (tumor volume increased to 1.05X), which shows that FH-MIPNPs/BLM had obvious targeted therapeutic effect compared to the other three control groups of BLM, FH-NIPNPs/BLM, and physiological saline (tumor volume increased to 1.5X, 1.6X, and 2.4X, respectively). What is more, FH-MIPNPs have low biotoxicity through toxicity experiments in vitro and in vivo, which is favorable toward making molecularly imprinted polymers an effective platform for tumor-targeted imaging and therapy.
WOS关键词SILICON NANOPARTICLES ; MEMBRANE-RECEPTORS ; FOLIC-ACID ; TEMPERATURE
资助项目National Natural Science Foundation of China[21775077] ; National Natural Science Foundation of China[21475069] ; Tianjin Natural Science Foundation[16JCZDJC37200]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000484831100094
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173207]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Li, Wen-You; Zhang, Yu-Kui
作者单位1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, Res Ctr Analyt Sci, State Key Lab Med Chem Biol,Coll Chem, Tianjin 300071, Peoples R China
2.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China
3.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China
4.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
5.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Jia, Chao,Zhang, Man,Zhang, Yan,et al. Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(35):32431-32440.
APA Jia, Chao.,Zhang, Man.,Zhang, Yan.,Ma, Zi-Bo.,Xiao, Nan-Nan.,...&Zhang, Yu-Kui.(2019).Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells.ACS APPLIED MATERIALS & INTERFACES,11(35),32431-32440.
MLA Jia, Chao,et al."Preparation of Dual-Template Epitope Imprinted Polymers for Targeted Fluorescence Imaging and Targeted Drug Delivery to Pancreatic Cancer BxPC-3 Cells".ACS APPLIED MATERIALS & INTERFACES 11.35(2019):32431-32440.

入库方式： OAI收割

来源：大连化学物理研究所

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