Smart polymer-based calcium-ion self-regulated nanochannels by mimicking the biological Ca2+-induced Ca2+ release process
文献类型：期刊论文
| 作者 | Li, Yunlong1,2; Xiong, Yuting2; Wang, Dongdong2; Li, Xiuling2; Chen, Zhixiang1,2; Wang, Cunli2; Qin, Haijuan3; Liu, Jinxuan4; Chang, Baisong1; Qing, Guangyan2 |
| 刊名 | NPG ASIA MATERIALS
 |
| 出版日期 | 2019-08-30 |
| 卷号 | 11页码:13 |
| ISSN号 | 1884-4049 |
| DOI | 10.1038/s41427-019-0148-4 |
| 通讯作者 | Qing, Guangyan(qinggy@dicp.ac.cn) |
| 英文摘要 | In nature, ion channels play key roles in controlling ion transport between cells and their surroundings. Calcium ion (Ca2+)-induced Ca2+ release (CICR), a critical control mechanism for Ca2+ channels, occurs due to a Ca2+ concentration gradient working in synergy with ryanodine receptors, which are famously known as "calcium sparks". Inspired by this self-regulated biological process, a smart Ca2+ concentration-modulated nanochannel system was developed by integrating a poly{N-isopropylacrylamide-co-acrylamide-[4-(trifluoromethyl) phenyl]-2-thiourea(0.2)-co-acrylamideDDDEEKC(0.2)} (denoted as PNI-co-CF3-PT0.2-co-DDDEEKC0.2) three-component copolymer onto the nanochannels of a porous anodic alumina (PAA) membrane. In this smart polymer design, the DDDEEKC hepta-peptide unit has an extraordinary binding affinity with Ca2+ through coordination bonds, while CF3-PT functions as a hydrogen bond mediation unit, facilitating the remarkable conformational transition of the PNI main chain in response to Ca2+-specific adsorption. Due to these futures, the dynamic gating behaviors of the modified nanochannels could be precisely manipulated by the Ca(2+)concentration. In addition, the sensitive Ca2+ response, as low as 10 pM with a high specificity toward Ca2+ capable of discriminating Ca2+ from other potential interference metal ions (e.g., K+, Cu2+, Mg2+, Zn2+, Fe3+, and Al3+), remarkable morphological change in the nanochannel and satisfactory reversibility indicate the great potential of Ca2+-responsive polymers for the fabrication of biodevices and artificial nanochannels. |
| WOS关键词 | STIMULI-RESPONSIVE POLYMER ; CONFORMATIONAL-CHANGE ; SELECTIVITY ; BINDING ; HYDROXYAPATITE ; FABRICATION ; TRANSPORT ; NANOPORES ; STATHERIN ; MEMBRANE |
| 资助项目 | National Natural Science Foundation of China[51473131] ; National Natural Science Foundation of China[51533007] ; National Natural Science Foundation of China[21775116] ; DICP Innovation Funding[DICP-RC201801] ; LiaoNing Revitalization Talents Program[XLYC1802109] ; Wuhan Morning Light Plan of Youth Science and Technology |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000483901600001 |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; LiaoNing Revitalization Talents Program ; LiaoNing Revitalization Talents Program ; Wuhan Morning Light Plan of Youth Science and Technology ; Wuhan Morning Light Plan of Youth Science and Technology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; LiaoNing Revitalization Talents Program ; LiaoNing Revitalization Talents Program ; Wuhan Morning Light Plan of Youth Science and Technology ; Wuhan Morning Light Plan of Youth Science and Technology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; LiaoNing Revitalization Talents Program ; LiaoNing Revitalization Talents Program ; Wuhan Morning Light Plan of Youth Science and Technology ; Wuhan Morning Light Plan of Youth Science and Technology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; LiaoNing Revitalization Talents Program ; LiaoNing Revitalization Talents Program ; Wuhan Morning Light Plan of Youth Science and Technology ; Wuhan Morning Light Plan of Youth Science and Technology |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/173317]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qing, Guangyan |
| 作者单位 | 1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Tianjin Univ Sci & Technol, Res Ctr Modern Analyt Technol, Tianjin, Peoples R China 4.Dalian Univ Technol, Inst Artificial Photosynth, State Key Lab Fine Chem, Dalian 116024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yunlong,Xiong, Yuting,Wang, Dongdong,et al. Smart polymer-based calcium-ion self-regulated nanochannels by mimicking the biological Ca2+-induced Ca2+ release process[J]. NPG ASIA MATERIALS,2019,11:13. |
| APA | Li, Yunlong.,Xiong, Yuting.,Wang, Dongdong.,Li, Xiuling.,Chen, Zhixiang.,...&Qing, Guangyan.(2019).Smart polymer-based calcium-ion self-regulated nanochannels by mimicking the biological Ca2+-induced Ca2+ release process.NPG ASIA MATERIALS,11,13. |
| MLA | Li, Yunlong,et al."Smart polymer-based calcium-ion self-regulated nanochannels by mimicking the biological Ca2+-induced Ca2+ release process".NPG ASIA MATERIALS 11(2019):13. |
入库方式： OAI收割
来源：大连化学物理研究所
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