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Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green

文献类型：期刊论文

作者Xu, Yuanyuan1,9; Long, Shan2; Yang, Yunning1,9; Zhou, Feifan3; Dong, Ning4; Yan, Kesong8; Wang, Bo5; Zeng, Yachao6; Du, Nan5; Li, Xiaosong5
刊名THEORETICAL BIOLOGY AND MEDICAL MODELLING
出版日期2019-08-19
卷号16期号:1页码:11
关键词Photothermal therapy Temperature distribution Indocyanine green Pennes bio-equation Monte Carlo COMSOL Multiphysics
DOI10.1186/s12976-019-0107-3
通讯作者Li, Xiaosong(doctor301@sohu.com)
英文摘要Background Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model. Results This study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 degrees C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 degrees C which located under the tumor tissue. The temperature difference was about 20 degrees C. Temperature distribution in tissue was not uniform. The temperature difference in different parts of tumor tissue raised up to 15 degrees C. The temperature of tumor tissue treated by laser combined with indocyanine green was about 20 degrees C higher than that of the surrounding healthy tissue. Conclusions Reasonably good matching between the calculated temperature and the measured temperature was achieved, thus demonstrated great utility of our modeling method and approaches for deepening understand in the temperature distribution in tumor tissue and surrounding healthy tissue during the laser combined with photosensitizer. The simulation model could provide guidance and reference function for the effect of photothermal therapy.
WOS关键词IN-VIVO ; THERMAL-PROPERTIES ; LIGHT-DISTRIBUTION ; OPTICAL-PROPERTIES ; HUMAN-SKIN ; ABLATION ; IMMUNOTHERAPY ; HYPERTHERMIA ; CANCER
资助项目National Key Research and Development Program of China[2018YFB0407200] ; National Natural Science Foundation of China[81572953]
WOS研究方向Mathematical & Computational Biology
语种英语
出版者BMC
WOS记录号WOS:000481744400001
资助机构National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173539]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Li, Xiaosong
作者单位1.Jinzhou Med Univ, Chinese PLA Gen Hosp, Grad Training Base Med Ctr 4, Dept Oncol, Beijing 100048, Peoples R China
2.Nankai Univ, Sch Med, Tianjin 300071, Peoples R China
3.Shenzhen Univ, Shenzhen 518000, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Burns Inst, Beijing 100048, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Oncol, Beijing 100048, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116000, Liaoning, Peoples R China
7.Univ Cent Oklahoma, Coll Math & Sci, Ctr Interdisciplinary Biomed Educ & Res, Biophoton Res Lab, Edmond, OK 73034 USA
8.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Lab Anim, Beijing 100048, Peoples R China
9.Jinzhou Med Univ, Jinzhou 121000, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Yuanyuan,Long, Shan,Yang, Yunning,et al. Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green[J]. THEORETICAL BIOLOGY AND MEDICAL MODELLING,2019,16(1):11.
APA Xu, Yuanyuan.,Long, Shan.,Yang, Yunning.,Zhou, Feifan.,Dong, Ning.,...&Chen, Wei R..(2019).Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green.THEORETICAL BIOLOGY AND MEDICAL MODELLING,16(1),11.
MLA Xu, Yuanyuan,et al."Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green".THEORETICAL BIOLOGY AND MEDICAL MODELLING 16.1(2019):11.

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来源：大连化学物理研究所

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