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Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection

文献类型：期刊论文

作者Wang, Weimin1,2; Wang, Shuang1,2; Xu, Chuting1,2; Li, Hong3; Xing, Yuming3; Hou, Keyong1; Li, Haiyang1
刊名ANALYTICAL CHEMISTRY
出版日期2019-08-06
卷号91期号:15页码:10212-10220
ISSN号0003-2700
DOI10.1021/acs.analchem.9b02309
通讯作者Hou, Keyong(houky@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要The increasing demand for rapid and sensitive roadside identification of trace illegal drugs drives the development of high-performance miniature mass spectrometric instrumentation and methodology. Here, we report a synchronized flash-thermal-desorption purging and ion injection (SFTDPI) method to increase the sensitive and rapid screening of volatile and nonvolatile illegal drugs for miniature ion trap mass spectrometry (ITMS). The flash-thermal desorption could reach 290 degrees C in 2.5 s, which could achieve efficient vaporization of nonvolatile noscapine with boiling point at 565 degrees C. ITMS using discontinuous atmospheric pressure interface (DAPI) has an ion utilization ratio of less than 1%, the synchronized purging for flash-thermal desorption and ion injection with DAPI could accurately control the time interval along with the desorption, gas purging, ionization and ion injection, and the sample utilization ratio increases more than five times. The miniature SFTDPI-ITMS presents good performance: (1) more than 60 times improvement in sensitivity was achieved compared to the previously reported thermal-desorption acetone-assisted photoionization ion trap mass spectrometer for nonvolatile drugs, and the minimum detectable quantity reaches 50 pg for fentanyl. (2) Ten kinds of mixing drugs with boiling point difference of 300 degrees C can be simultaneously identified within 3 s under a single analysis. SFTDPI-ITMS was deployed at the roadside checkpoint of Sino-Burmese border; fentanyl in the captured encapsulated powder and the suspected opiate had been successfully identified.
WOS关键词VAPOR-PRESSURE ; ILLICIT DRUGS ; FENTANYL ; ABUSE ; IDENTIFICATION ; VAPORIZATION ; ENTHALPY ; HEROIN ; DART
资助项目National Natural Science Foundation of China[21675155] ; National Natural Science Foundation of China[21874134] ; National Key Research and Development Program of China[2016YFC0800902] ; DICP[DICP ZZBS201701]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000480499200118
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173588]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Hou, Keyong; Li, Haiyang
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Yunnan Police Officer Acad, 249 Jiaochang North Rd, Kunming 650223, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Weimin,Wang, Shuang,Xu, Chuting,et al. Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection[J]. ANALYTICAL CHEMISTRY,2019,91(15):10212-10220.
APA Wang, Weimin.,Wang, Shuang.,Xu, Chuting.,Li, Hong.,Xing, Yuming.,...&Li, Haiyang.(2019).Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection.ANALYTICAL CHEMISTRY,91(15),10212-10220.
MLA Wang, Weimin,et al."Rapid Screening of Trace Volatile and Nonvolatile Illegal Drugs by Miniature Ion Trap Mass Spectrometry: Synchronized Flash-Thermal-Desorption Purging and Ion Injection".ANALYTICAL CHEMISTRY 91.15(2019):10212-10220.

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来源：大连化学物理研究所

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