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A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines

文献类型：期刊论文

作者Yu, Chang-Bin1; Li, Xiang1; Zhou, Yong-Gui1,2
刊名ASIAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-07-01
卷号8期号:7页码:1118-1121
ISSN号2193-5807
关键词palladium asymmetric hydrogenation tandem reactions indoles 2 3-disubstituted indolines
DOI10.1002/ajoc.201900289
通讯作者Yu, Chang-Bin(cbyu@dicp.ac.cn) ; Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要A divergent and enantioselective procedure for synthesis of 2,3-disubstituted indolines was developed through Bronsted acid/palladium-complex promoted condensation/reductive alkylation/ hydrogenation cascade reactions from simple amino ketones and aldehydes in one operation. Five Bronsted acid-promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process. This strategy provides facile synthesis of structurally diverse multi-substituted chiral indolines.
WOS关键词CATALYZED ASYMMETRIC HYDROGENATION ; KINETIC RESOLUTION ; TANDEM ; INDOLES ; CYCLOADDITIONS ; HETEROCYCLES ; ALKALOIDS ; DIVERGENT ; ACCESS
资助项目National Natural Science Foundation of China[21871255] ; National Natural Science Foundation of China[21532006] ; Strategic Priority Program of the Chinese Academy of Sciences[XDB17020300]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000477988300033
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences
源URL[http://cas-ir.dicp.ac.cn/handle/321008/173872]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Yu, Chang-Bin; Zhou, Yong-Gui
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714		 Yu, Chang-Bin,Li, Xiang,Zhou, Yong-Gui. A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2019,8(7):1118-1121.
APA Yu, Chang-Bin,Li, Xiang,&Zhou, Yong-Gui.(2019).A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines.ASIAN JOURNAL OF ORGANIC CHEMISTRY,8(7),1118-1121.
MLA Yu, Chang-Bin,et al."A Condensation/Reductive Alkylation/Hydrogenation Cascade for Facile Synthesis of Chiral 2,3-Disubstituted Indolines".ASIAN JOURNAL OF ORGANIC CHEMISTRY 8.7(2019):1118-1121.

入库方式： OAI收割

来源：大连化学物理研究所

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