Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | He, Hui2; Chen, Di1; Cui, Shimeng3; Piao, Hailong1; Tang, Haibo2; Wang, Xun2; Ye, Peng4; Jin, Shi2 |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 42期号:2页码:745-752 |
| 关键词 | lncRNA ceRNA network HCC OIP5-AS1 topological analysis |
| ISSN号 | 1021-335X |
| DOI | 10.3892/or.2019.7181 |
| 通讯作者 | Jin, Shi(jinshi_1969@hotmail.com) |
| 英文摘要 | The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network-based correlation analysis and expression-based Spearman correlation coefficients were utilized to identify potential mRNA-lncRNA interactions. Then, a competitive endogenous (ce)RNA network was constructed from these interactions, and network topology and Gene Ontology enrichment analyses were conducted to mine potential functions of ceRNAs. In HCC samples, a ceRNA network was constructed. It was composed of 35,657 edges connecting 113 lncRNAs and 6,136 mRNAs which were differentially expressed in HCC and normal liver tissues. Meanwhile, a number of significantly positively correlated mRNA and lncRNA pairs in this ceRNA network were found to be consistently positively correlated in another independent dataset. To be noted, further analyses on the potential roles of ceRNAs demonstrated than various lncRNAs such as LINC00657, TUG1 and SNHG1 may play key roles in HCC by regulating protein phosphorylation or cell cycle pathways or influencing miRNAs. From the perspective that lncRNAs can function as ceRNAs, this study revealed that the interaction between lncRNAs, miRNAs and mRNAs may provide new insight for the diagnosis and treatment in the tumorigenesis of hepatocellular carcinoma. |
| WOS关键词 | PROGNOSTIC MARKERS ; CERNA ; MICRORNAS ; LNCRNA ; CHEMOPREVENTION ; PROLIFERATION ; EXPRESSION ; SPONGES ; OBESITY ; CANCER |
| 资助项目 | National Natural Science Foundation of China[NSFC 81702526] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000475611600024 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/173954]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Jin, Shi |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dept Laparoscop Surg, 193 Lianhe Rd, Dalian 116000, Liaoning, Peoples R China 3.Dalian Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Dalian 116000, Liaoning, Peoples R China 4.Liaoning Canc Hosp & Inst, Dept Urol Surg, Shenyang 110042, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Hui,Chen, Di,Cui, Shimeng,et al. Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma[J]. ONCOLOGY REPORTS,2019,42(2):745-752. |
| APA | He, Hui.,Chen, Di.,Cui, Shimeng.,Piao, Hailong.,Tang, Haibo.,...&Jin, Shi.(2019).Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma.ONCOLOGY REPORTS,42(2),745-752. |
| MLA | He, Hui,et al."Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma".ONCOLOGY REPORTS 42.2(2019):745-752. |
入库方式： OAI收割
来源：大连化学物理研究所
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