Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures
文献类型：期刊论文
| 作者 | Chen, Hong1,2; Chen, Chuang2; Huang, Wei2; Li, Mei1,2; Xiao, Yao1,2; Jiang, Dandan2; Li, Haiyang2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2019-07-16 |
| 卷号 | 91期号:14页码:9138-9146 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.9b01700 |
| 通讯作者 | Chen, Chuang(chenchuang@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn) |
| 英文摘要 | The hidden presence of fentanyl and new psychoactive substances in established illicit drugs has led to a great number of unintentional fatal overdoses, justifying the urgent need for portable tools for the rapid screening of various drugs. Ion mobility spectrometry, as a rapid detection technique, has been widely used in detecting illicit drugs, whereas it is insufficiently sensitive for bigger ions due to the mobility discrimination of an ion shutter. In this work, a miniaturized ion mobility spectrometer with an inner diameter of 14 mm and a drift length of 38.9 mm and equipped with a novel dual-compression tristate ion shutter has been developed, which could greatly reduce the mobility discrimination by compressing the ion packet twice during the injection process. The best gating performance of the dual-compression tristate ion shutter was about three times as high as that of the tristate ion shutter and twice as high as that of the Tyndall-Powell shutter. For example, the peak height was increased by 150 or 40% when the resolving power was the same, whereas the resolution of two neighboring peaks was improved by 46 or 19% when the peak heights were the same. In screening of fentanyl drug mixtures, the new shutter enhanced the identification accuracy of constituents by making peaks of slow dimer ions and complex ions observable. Besides, the new shutter helped to achieve high sensitivity for drug ions spreading a wide ion mobility range from 0.644 to 2.032 cm(2) s(-1) V-1, demonstrating its potential use in the analysis of other mixtures and the detection of large ions. |
| WOS关键词 | THERMAL-DESORPTION ; COCAINE ; MS ; TRANSMISSION ; OPIATES ; COMPLEX ; URINE ; ABUSE |
| 资助项目 | National Key R&D Program of China[2016YFC0201200] ; National Key R&D Program of China[2016YFC0800912] ; National Natural Science Foundation of China[21405158] ; National Natural Science Foundation of China[21707138] ; Dalian Institute of Chemical Physics[DICP ZZBS201709] ; Dalian Institute of Chemical Physics[DICP ZZBS201801] ; Dalian Institute of Chemical Physics[DICPZZBS201808] ; Scientific Study Project of Liaoning Province Educational Commission of China[LQ201715001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000476567700055 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/173981]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Chuang; Li, Haiyang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Hong,Chen, Chuang,Huang, Wei,et al. Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures[J]. ANALYTICAL CHEMISTRY,2019,91(14):9138-9146. |
| APA | Chen, Hong.,Chen, Chuang.,Huang, Wei.,Li, Mei.,Xiao, Yao.,...&Li, Haiyang.(2019).Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures.ANALYTICAL CHEMISTRY,91(14),9138-9146. |
| MLA | Chen, Hong,et al."Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures".ANALYTICAL CHEMISTRY 91.14(2019):9138-9146. |
入库方式： OAI收割
来源：大连化学物理研究所
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