Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo
文献类型：期刊论文
| 作者 | Guangchun Ji2; Fei Song2; Qi Xing2; Jian Liu2; Kedong Song1; Daqing Zhang2; Zihan Wang3 |
| 刊名 | Neural Regeneration Research
 |
| 出版日期 | 2011-01-01 |
| 卷号 | 6期号:19页码:1462 |
| ISSN号 | 1673-5374 |
| 英文摘要 | This experiment sought to observe the migration and distribution of bone mesenchymal stem cells transfected with the cytosine deaminase gene (BMSCs-CD/eGFP) after transplantation in vivo through three pathways. In addition, we examined the tropism of these cells to glioma. Intracranial C6 glioma models were established in Sprague-Dawley rats using an intracranial stereotactic inoculation method. When tumors were 7 days old, rats were inoculated with 1x10(6) BMSCs-CD/eGFP cells via the tumor-bearing internal carotid artery, the contralateral hemisphere and the tumor-bearing glioma. Fluorescence microscopy revealed that BMSCs-CD/eGFP exhibited a strong capacity for migration to tumors. BMSCs-CD/eGFP transplanted via the tumor-bearing internal carotid artery were observed to distribute in glioma tissues. BMSCs-CD/eGFP inoculated via the ipsilateral glioma mainly located within and at the edge of glioma tissues. BMSCs-CD/eGFP inoculated via the contralateral hemisphere mainly distributed at the proximal end of the tumor at the incubation site. |
| 资助项目 | [Natural Science Foundation of Liaoning Province, China] |
| 语种 | 英语 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/175089]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Institute of Chemical Engineering,Dalian University of Technology/Dalian Stem Cell and Tissue Engineering Research and Development Center 2.大连医科大学 3.中国科学院大连化学物理研究所 |
| 推荐引用方式 GB/T 7714 | Guangchun Ji,Fei Song,Qi Xing,et al. Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo[J]. Neural Regeneration Research,2011,6(19):1462. |
| APA | Guangchun Ji.,Fei Song.,Qi Xing.,Jian Liu.,Kedong Song.,...&Zihan Wang.(2011).Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo.Neural Regeneration Research,6(19),1462. |
| MLA | Guangchun Ji,et al."Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo".Neural Regeneration Research 6.19(2011):1462. |
入库方式： OAI收割
来源：大连化学物理研究所
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