Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum
文献类型：期刊论文
| 作者 | Shen, Li1,3,4,5; Ai, Chun-Zhi2; Song, Yong-Chun4; Wang, Feng-Wu4; Jiao, Rui-Hua4; Zhang, Ai-Hua4; Man, Hui-Zi6; Tan, Ren-Xiang4 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 82期号:6页码:1503-1509 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b01034 |
| 通讯作者 | Shen, Li(shenli@yzu.edu.cn) |
| 英文摘要 | Six new macrolides named myrothecines D-G (1-4), 16-hydroxymytoxin B (5), and 14'-dehydrovertisporin (6), including four 10,13-cyclotrichothecane derivatives, in addition to 12 known compounds (7-18), were isolated from three endophytic Myrothecium roridum, IFB-E008, IFB-E009, and IFB-E012. The isolated compounds were characterized by MS, NMR, CD, and single-crystal X-ray crystallography. The isolated macrolides exhibited an antiproliferation effect against chronic myeloid leukemia K562 and colorectal carcinoma SW1116 cell lines. Compounds 1-6 were cytotoxic, with IC50 values ranging between 56 nM and 16 mu M. Since slight structural changes led to obvious activity differences, the CoMFA (comparative analysis) and CoMSIA (comparative molecular similarity indices analysis) methods were then used to explore the 3D QSAR (three-dimensional quantitative structure activity relationship) of these macrolides. The result showed that the steric, electrostatic, hydrophobic, and H-bond acceptor factors were involved in their cytotoxicity and provided an in-depth understanding of the structure activity relationships of these metabolites. |
| WOS关键词 | MACROCYCLIC TRICHOTHECENES ; CHEMICAL MODIFICATION ; VERRUCARIN-A ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[21372191] ; National Natural Science Foundation of China[81121062] ; National Natural Science Foundation of China[21132004] ; National Natural Science Foundation of China[21072092] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000473827300013 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/175246]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Shen, Li |
| 作者单位 | 1.Yangzhou Univ, Med Coll, Inst Translat Med, Yangzhou 225001, Jiangsu, Peoples R China 2.Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Inst Adv Study,Lab Optoelect Devices & Syst, Shenzhen 518061, Peoples R China 3.Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China 4.Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China 5.Yangzhou Univ, Coll Vet Med, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Li,Ai, Chun-Zhi,Song, Yong-Chun,et al. Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1503-1509. |
| APA | Shen, Li.,Ai, Chun-Zhi.,Song, Yong-Chun.,Wang, Feng-Wu.,Jiao, Rui-Hua.,...&Tan, Ren-Xiang.(2019).Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum.JOURNAL OF NATURAL PRODUCTS,82(6),1503-1509. |
| MLA | Shen, Li,et al."Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1503-1509. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。