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Advances in Hydrogels in Organoids and Organs-on-a-Chip

文献类型：期刊论文

作者Liu, Haitao2,3; Wang, Yaqing2,3; Cui, Kangli2,3; Guo, Yaqiong2,3; Zhang, Xu4; Qin, Jianhua1,2,3,5
刊名ADVANCED MATERIALS
出版日期2019-07-08
页码28
ISSN号0935-9648
关键词3D tissue models hydrogels organoids organs-on-a-chip stem cells
DOI10.1002/adma.201902042
通讯作者Qin, Jianhua(jhqin@dicp.ac.cn)
英文摘要Significant advances in materials, microscale technology, and stem cell biology have enabled the construction of 3D tissues and organs, which will ultimately lead to more effective diagnostics and therapy. Organoids and organs-on-a-chip (OOC), evolved from developmental biology and bioengineering principles, have emerged as major technological breakthrough and distinct model systems to revolutionize biomedical research and drug discovery by recapitulating the key structural and functional complexity of human organs in vitro. There is growing interest in the development of functional biomaterials, especially hydrogels, for utilization in these promising systems to build more physiologically relevant 3D tissues with defined properties. The remarkable properties of defined hydrogels as proper extracellular matrix that can instruct cellular behaviors are presented. The recent trend where functional hydrogels are integrated into organoids and OOC systems for the construction of 3D tissue models is highlighted. Future opportunities and perspectives in the development of advanced hydrogels toward accelerating organoids and OOC research in biomedical applications are also discussed.
WOS关键词PLURIPOTENT STEM-CELLS ; BLOOD-BRAIN-BARRIER ; IN-VITRO ; CEREBRAL ORGANOIDS ; MICROFLUIDIC PLATFORM ; INTESTINAL ORGANOIDS ; ENDOTHELIAL-CELLS ; COLORECTAL-CANCER ; DEFINED HYDROGEL ; HUMAN LIVER
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32020200] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29050301] ; National Key R&D Program of China[2017YFB0405400] ; National Major Scientific and Technological Special Project[2018ZX09201017] ; National Natural Science Foundation of China[31671038] ; National Natural Science Foundation of China[81803492] ; Innovation Program of Science and Research from the DICP[DICP TMSR201601]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000474647300001
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Major Scientific and Technological Special Project ; National Major Scientific and Technological Special Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovation Program of Science and Research from the DICP ; Innovation Program of Science and Research from the DICP ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Major Scientific and Technological Special Project ; National Major Scientific and Technological Special Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovation Program of Science and Research from the DICP ; Innovation Program of Science and Research from the DICP ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Major Scientific and Technological Special Project ; National Major Scientific and Technological Special Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovation Program of Science and Research from the DICP ; Innovation Program of Science and Research from the DICP ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Major Scientific and Technological Special Project ; National Major Scientific and Technological Special Project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Innovation Program of Science and Research from the DICP ; Innovation Program of Science and Research from the DICP
源URL[http://cas-ir.dicp.ac.cn/handle/321008/175309]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Qin, Jianhua
作者单位1.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
5.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Haitao,Wang, Yaqing,Cui, Kangli,et al. Advances in Hydrogels in Organoids and Organs-on-a-Chip[J]. ADVANCED MATERIALS,2019:28.
APA Liu, Haitao,Wang, Yaqing,Cui, Kangli,Guo, Yaqiong,Zhang, Xu,&Qin, Jianhua.(2019).Advances in Hydrogels in Organoids and Organs-on-a-Chip.ADVANCED MATERIALS,28.
MLA Liu, Haitao,et al."Advances in Hydrogels in Organoids and Organs-on-a-Chip".ADVANCED MATERIALS (2019):28.

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来源：大连化学物理研究所

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