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Chiral Phosphoric Acid-Catalyzed Synthesis of Fluorinated 5,6-Dihydroindolo[1,2-c]quinazolines with Quaternary Stereocenters

文献类型：期刊论文

作者Wang, Xin-Wei1,2,3; Chen, Mu-Wang1; Wu, Bo1; Wang, Baomin3; Zhou, Yong-Gui1,2
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-06-21
卷号84期号:12页码:8300-8308
ISSN号0022-3263
DOI10.1021/acs.joc.9b00985
通讯作者Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要A chiral phosphoric acid-catalyzed enantioselective synthesis of fluorinated 5,6-dihydroindolo[1,2-c]quinazolines has been developed by a condensation/amine addition cascade from 2-(1H-indoly)anilines and fluorinated ketones, giving the fluorinated aminals with quaternary stereogenic centers with excellent yields and up to 97% ee. A series of the fluorinated aromatic, aliphatic ketones, and ethyl trifluoropyruvate are suitable.
WOS关键词HIGHLY ENANTIOSELECTIVE SYNTHESIS ; ASYMMETRIC 3+2 CYCLOADDITION ; AZOMETHINE YLIDES ; INTRAMOLECULAR AMIDATION ; DIHYDROQUINAZOLINONES ; 2,3-DIHYDROQUINAZOLINONES ; IMIDAZOLIDINES ; CONSTRUCTION ; ALKALOIDS ; RECEPTOR
资助项目National Natural Science Foundation of China[21532006] ; National Natural Science Foundation of China[21690074] ; Chinese Academy of Sciences[XDB17020300] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH035]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000473116200072
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences
源URL[http://cas-ir.dicp.ac.cn/handle/321008/175398]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Zhou, Yong-Gui
作者单位1.Chinese Acad Sci, State Key Lab Catalysis, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xin-Wei,Chen, Mu-Wang,Wu, Bo,et al. Chiral Phosphoric Acid-Catalyzed Synthesis of Fluorinated 5,6-Dihydroindolo[1,2-c]quinazolines with Quaternary Stereocenters[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(12):8300-8308.
APA Wang, Xin-Wei,Chen, Mu-Wang,Wu, Bo,Wang, Baomin,&Zhou, Yong-Gui.(2019).Chiral Phosphoric Acid-Catalyzed Synthesis of Fluorinated 5,6-Dihydroindolo[1,2-c]quinazolines with Quaternary Stereocenters.JOURNAL OF ORGANIC CHEMISTRY,84(12),8300-8308.
MLA Wang, Xin-Wei,et al."Chiral Phosphoric Acid-Catalyzed Synthesis of Fluorinated 5,6-Dihydroindolo[1,2-c]quinazolines with Quaternary Stereocenters".JOURNAL OF ORGANIC CHEMISTRY 84.12(2019):8300-8308.

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来源：大连化学物理研究所

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