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Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

文献类型：期刊论文

作者Lu, Xuefei1; Zhu, Yong1; Bai, Ru1,2,3; Wu, Zhengsheng4; Qian, Wenchang1; Yang, Leiyan1; Cai, Rong2,3; Yan, Hong5; Li, Tao6; Pandey, Vijay7
刊名NATURE NANOTECHNOLOGY
出版日期2019-07-01
卷号14期号:7页码:719-+
ISSN号1748-3387
DOI10.1038/s41565-019-0472-4
通讯作者Chen, Chunying(chenchy@nanoctr.cn) ; Zhu, Tao(zhut@ustc.edu.cn)
英文摘要Anthropogenic carbon nanotubes, with a fibrous structure and physical properties similar to asbestos, have recently been found within human lung tissues. However, the reported carbon-nanotube-elicited pulmonary pathologies have been mostly confined to inflammatory or neoplastic lesions in the lungs or adjacent tissues. In the present study, we demonstrate that a single pulmonary exposure to multi-walled carbon nanotubes dramatically enhances angiogenesis and the invasiveness of orthotopically implanted mammary carcinoma, leading to metastasis and rapid colonization of the lungs and other organs. Exposure to multi-walled carbon nanotubes stimulates local and systemic inflammation, contributing to the formation of pre-metastatic and metastatic niches. Our study suggests that nanoscale-material-elicited pulmonary lesions may exert complex and extended influences on tumour progression. Given the increasing presence of carbon nanotubes in the environment, this report emphasizes the urgent need to escalate efforts assessing the long-term risks of airborne nanomaterial exposure in non-lung cancer progression.
WOS关键词TUMOR-GROWTH ; TRANSFORMATION ; ANGIOGENESIS ; INSIGHTS ; TISSUE ; CAVITY ; CELLS
资助项目National Key RAMP;D Program of China[2016YFC1302305] ; National Key RAMP;D Program of China[2016YFA0201600] ; National Key RAMP;D Program of China[2016YFE0133100] ; National Natural Science Foundation of China[81672615] ; National Natural Science Foundation of China[815022829] ; National Natural Science Foundation of China[91543206] ; National Natural Science Foundation of China[31622026] ; National Natural Science Foundation of China[31700879] ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China[11621505] ; Shenzhen Development and Reform Commission Subject Construction Project[[2017]1434] ; Bureau of International Co-operation Chinese Academy of Sciences[GJHG1852] ; National Science Fund for Distinguished Young Scholars[11425520]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000473760300025
资助机构National Key RAMP;D Program of China ; National Key RAMP;D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Shenzhen Development and Reform Commission Subject Construction Project ; Shenzhen Development and Reform Commission Subject Construction Project ; Bureau of International Co-operation Chinese Academy of Sciences ; Bureau of International Co-operation Chinese Academy of Sciences ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Key RAMP;D Program of China ; National Key RAMP;D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Shenzhen Development and Reform Commission Subject Construction Project ; Shenzhen Development and Reform Commission Subject Construction Project ; Bureau of International Co-operation Chinese Academy of Sciences ; Bureau of International Co-operation Chinese Academy of Sciences ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Key RAMP;D Program of China ; National Key RAMP;D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Shenzhen Development and Reform Commission Subject Construction Project ; Shenzhen Development and Reform Commission Subject Construction Project ; Bureau of International Co-operation Chinese Academy of Sciences ; Bureau of International Co-operation Chinese Academy of Sciences ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Key RAMP;D Program of China ; National Key RAMP;D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Science Fund for Creative Research Groups of the National Natural Science Foundation of China ; Shenzhen Development and Reform Commission Subject Construction Project ; Shenzhen Development and Reform Commission Subject Construction Project ; Bureau of International Co-operation Chinese Academy of Sciences ; Bureau of International Co-operation Chinese Academy of Sciences ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars
源URL[http://cas-ir.dicp.ac.cn/handle/321008/175478]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Chen, Chunying; Zhu, Tao
作者单位1.Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, Hefei Natl Lab Phys Sci Microscale, Sch Biomed Engn,Fac Life Sci & Med, Hefei, Anhui, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China
3.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing, Peoples R China
4.Anhui Med Univ, Dept Pathol, Hefei, Anhui, Peoples R China
5.Univ Sci & Technol China, Affiliated Hosp 1, Anhui Prov Canc Hosp, Dept Pathol, Hefei, Anhui, Peoples R China
6.Anhui Med Univ, Affiliated Hosp 1, Dept Clin Lab, Hefei, Anhui, Peoples R China
7.Tsinghua Univ, Tsinghua Berkeley Shenzhen Inst, Shenzhen, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Xuefei,Zhu, Yong,Bai, Ru,et al. Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades[J]. NATURE NANOTECHNOLOGY,2019,14(7):719-+.
APA Lu, Xuefei.,Zhu, Yong.,Bai, Ru.,Wu, Zhengsheng.,Qian, Wenchang.,...&Zhu, Tao.(2019).Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades.NATURE NANOTECHNOLOGY,14(7),719-+.
MLA Lu, Xuefei,et al."Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades".NATURE NANOTECHNOLOGY 14.7(2019):719-+.

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来源：大连化学物理研究所

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