One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System
文献类型：期刊论文
| 作者 | Wang, Hui1,2; Liu, Haitao1; Liu, Hui1; Su, Wentao1; Chen, Wenwen1,2; Qin, Jianhua1,2,3,4 |
| 刊名 | ADVANCED MATERIALS TECHNOLOGIES
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 4期号:6页码:10 |
| 关键词 | core-shell gels droplet microfluidics gelatin methacrylate (GelMA) microgels |
| ISSN号 | 2365-709X |
| DOI | 10.1002/admt.201800632 |
| 通讯作者 | Qin, Jianhua(jhqin@dicp.ac.cn) |
| 英文摘要 | Gelatin methacrylate (GelMA) microgels are promising scaffolds for biological applications, such as tissue engineering and drug screening. Solid-like GelMA microgels are limited by undefined spatial structures and inadequate protection. In this study, a simple strategy is reported for the one-step generation of core-shell GelMA microgels using a droplet microfluidic system. A flow-focusing microfluidic device is fabricated to produce the core-shell microgels. The device operates the laminar flow of a photocurable GelMA solution and a templated methyl cellulose solution in the system. The size of the microgels is controlled by simply adjusting the flow rates. The good biocompatibility of the microgels is demonstrated by encapsulating liver cells into the cores, in which the cells show high viability for 15 d. The microgels are also successfully used to coculture the liver cells and vascular endothelial cells, indicating the core-shell architectures are suitable for heterogenous cell cultures. The proposed core-shell GelMA microgels have potential in various fields such as the construction of microtissues, generation of organoids, and fabrication of stimuli-responsive materials. |
| WOS关键词 | HYDROGEL ; CELLS ; MICROCAPSULES ; FABRICATION |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29050301] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; National Key R&D Program of China[2017YFB0405400] ; Key Program of the Chinese Academy of Sciences[KFZD-SW-213] ; National Nature Science Foundation of China[91543121] ; National Nature Science Foundation of China[31671038] ; National Nature Science Foundation of China[81703470] ; National Nature Science Foundation of China[81603075] ; Innovation Program of Science and Research from the DICP, CAS[DICP TMSR201601] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000474175500006 |
| 出版者 | WILEY |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/175504]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qin, Jianhua |
| 作者单位 | 1.Chinese Acad Sci, DICP, CAS Key Lab Separat Sci Analyt Chem, Div Biotechnol, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Liu, Haitao,Liu, Hui,et al. One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System[J]. ADVANCED MATERIALS TECHNOLOGIES,2019,4(6):10. |
| APA | Wang, Hui,Liu, Haitao,Liu, Hui,Su, Wentao,Chen, Wenwen,&Qin, Jianhua.(2019).One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System.ADVANCED MATERIALS TECHNOLOGIES,4(6),10. |
| MLA | Wang, Hui,et al."One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System".ADVANCED MATERIALS TECHNOLOGIES 4.6(2019):10. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。