中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 大连化学物理研究所
  3. 中国科学院大连化学物理研究所
Iridium-catalyzed asymmetric hydrogenation of quinazolinones

文献类型：期刊论文

作者Feng, Guang-Shou1; Zhao, Zi-Biao1; Shi, Lei2; Zhou, Yong-Gui1,2
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2019-07-07
卷号6期号:13页码:2250-2253
ISSN号2052-4129
DOI10.1039/c9qo00443b
通讯作者Shi, Lei(shileichem@dlut.ac.cn) ; Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要Enantioselective hydrogenation of quinazolinones has been successfully realized by employing a chiral iridium/diphosphine complex as catalyst, furnishing the chiral dihydroquinazolinones with excellent yield and up to 98% enantioselectivity. Asymmetric hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity. Using the above methodology as the key step, the enantiopure bioactive Eg5 inhibitor and (-)-SDZ 267-489 could also be conveniently synthesized.
WOS关键词ENANTIOSELECTIVE HYDROGENATION ; EXCHANGER INHIBITOR ; DESIGN ; IMINES
资助项目National Natural Science Foundation of China[21532006] ; National Natural Science Foundation of China[2177219] ; Dalian Bureau of Science and Technology[2016RD07] ; Chinese Academy of Sciences[XDB17020300] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH035]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000472787400011
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Chinese Academy of Sciences ; Chinese Academy of Sciences
源URL[http://cas-ir.dicp.ac.cn/handle/321008/175665]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Shi, Lei; Zhou, Yong-Gui
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Guang-Shou,Zhao, Zi-Biao,Shi, Lei,et al. Iridium-catalyzed asymmetric hydrogenation of quinazolinones[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(13):2250-2253.
APA Feng, Guang-Shou,Zhao, Zi-Biao,Shi, Lei,&Zhou, Yong-Gui.(2019).Iridium-catalyzed asymmetric hydrogenation of quinazolinones.ORGANIC CHEMISTRY FRONTIERS,6(13),2250-2253.
MLA Feng, Guang-Shou,et al."Iridium-catalyzed asymmetric hydrogenation of quinazolinones".ORGANIC CHEMISTRY FRONTIERS 6.13(2019):2250-2253.

入库方式： OAI收割

来源：大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。