amphiphilicsodiumalginatevinylacetatemicroparticlesfordrugdelivery
文献类型：期刊论文
| 作者 | YU Weiting2; ZHANG Demeng3; LIU Xiudong1; WANG Yunhong1; TONG Jun1; ZHANG Mengxue4; MA Xiaojun5 |
| 刊名 | 海洋湖沼学报英文
 |
| 出版日期 | 2019-01-01 |
| 卷号 | 037期号:003页码:855 |
| ISSN号 | 2096-5508 |
| 英文摘要 | To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers,hydrophobic molecule(vinyl acetate,VAc)was grafted on alginate(Alg),which was further used to prepare drug carriers.Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin(BSA).Then,chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS)microcapsules.The BSA-loading amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS)microcapsules display similar morphology and size to the hydrophilic alginate/chitosan(AC)microcapsules.However,the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher,and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower.The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA,and the higher degree of substitution is,the slower the release rate is.In addition,the complex membrane can also be adjusted to delay the release of BSA.As a whole,amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery. |
| 资助项目 | [National Natural Science Foundation of China] ; [Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances] ; [National Undergraduates Innovation and Entrepreneurship Training Program of China] |
| 语种 | 英语 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/175723]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.College of Environment and Chemical Engineering,Dalian University,Dalian Economic Technological Development Zone 2.大连大学 3.中国科学院海洋研究所 4.State Key Laboratory of Bioactive Seaweed Substances,Qingdao Brightmoon Seaweed Group Co.Ltd. 5.中国科学院大连化学物理研究所 |
| 推荐引用方式 GB/T 7714 | YU Weiting,ZHANG Demeng,LIU Xiudong,et al. amphiphilicsodiumalginatevinylacetatemicroparticlesfordrugdelivery[J]. 海洋湖沼学报英文,2019,037(003):855. |
| APA | YU Weiting.,ZHANG Demeng.,LIU Xiudong.,WANG Yunhong.,TONG Jun.,...&MA Xiaojun.(2019).amphiphilicsodiumalginatevinylacetatemicroparticlesfordrugdelivery.海洋湖沼学报英文,037(003),855. |
| MLA | YU Weiting,et al."amphiphilicsodiumalginatevinylacetatemicroparticlesfordrugdelivery".海洋湖沼学报英文 037.003(2019):855. |
入库方式： OAI收割
来源：大连化学物理研究所
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