cAMP-modulated biomimetic ionic nanochannels based on a smart polymer
文献类型：期刊论文
| 作者 | Chen, Zhixiang1,2; Sun, Taolei2; Qing, Guangyan1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2019-06-21 |
| 卷号 | 7期号:23页码:3710-3715 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c9tb00639g |
| 通讯作者 | Qing, Guangyan(qinggy@dicp.ac.cn) |
| 英文摘要 | The flow of ions across the cell membrane is essential to many life processes. Cyclic 30,50-adenosine monophosphate (cAMP) binds to and regulates the function of cyclic nucleotide-gating channel proteins, which directly mediate the Na+/ Ca2+ transmembrane behaviours. This inspires us to develop a biomimetic cAMP-modulated ionic nanochannel based on a cAMP-responsive polymer design. Driven by specific hydrogen bonding interactions with cAMP, an arginine-based smart copolymer film displays remarkable adsorption toward cAMP and can clearly discriminate cAMP from other nucleotides, accompanied with reversible conformational transition of the polymer chain from a contracted state to a swollen one. Benefiting from these features, dynamic gating behaviours of the nanochannels located on the copolymer-modified anodic aluminum oxide (AAO) membrane could be precisely manipulated by cAMP. Sensitive responsiveness (10 pmol L 1) and high specificity toward cAMP, high controllability and satisfactory reversibility reveal the great potential of biomolecule responsive polymers in biomimetic nanochannels and nanodevices. |
| WOS关键词 | QUARTZ-CRYSTAL MICROBALANCE ; STIMULI-RESPONSIVE POLYMER ; CONFORMATIONAL-CHANGE ; NANOPORES ; DESIGN ; CONDUCTION ; CHANNELS ; SENSORS ; CHAINS |
| 资助项目 | National Natural Science Foundation of China[51473131] ; National Natural Science Foundation of China[51533007] ; National Natural Science Foundation of China[21775116] ; DICP Innovation Funding[DICP-RC201801] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000471134900009 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP Innovation Funding ; DICP Innovation Funding |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/175776]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qing, Guangyan |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Zhixiang,Sun, Taolei,Qing, Guangyan. cAMP-modulated biomimetic ionic nanochannels based on a smart polymer[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(23):3710-3715. |
| APA | Chen, Zhixiang,Sun, Taolei,&Qing, Guangyan.(2019).cAMP-modulated biomimetic ionic nanochannels based on a smart polymer.JOURNAL OF MATERIALS CHEMISTRY B,7(23),3710-3715. |
| MLA | Chen, Zhixiang,et al."cAMP-modulated biomimetic ionic nanochannels based on a smart polymer".JOURNAL OF MATERIALS CHEMISTRY B 7.23(2019):3710-3715. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。