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Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds

文献类型：期刊论文

作者Chen, Xuan2,3; Hua, Lei2; Jiang, Jichun2; Hu, Fan1; Wan, Ningbo2,3; Li, Haiyang2
刊名TALANTA
出版日期2019-08-15
卷号201页码:33-39
关键词High-pressure photoionization time-of-flight mass-spectrometry Multi-capillary column Rapid analysis Matrix effect Isomer separation Flavor compounds High-pressure photoionization time-of-flight mass-spectrometry Multi-capillary column Rapid analysis Matrix effect Isomer separation Flavor compounds
ISSN号0039-9140
DOI10.1016/j.talanta.2019.03.103
通讯作者Hua, Lei(lhua@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要High-pressure photoionization time-of-flight mass spectrometry (HPPI-TOFMS) is a versatile and highly sensitive analytical technique for online and real-time analysis of trace volatile organic compounds in complex mixtures. However, discrimination of isomers is usually a great challenge for the soft ionization method, and matrix effect is also inevitable under high pressure in the HPPI source. In this work, we describe a first attempt to develop a two-dimensional (2D) hyphenated instrument by coupling of a multi-capillary column (MCC) with a HPPI-TOFMS to overcome these problems. The capability of the MCC-HPPI-TOFMS for discrimination of isomeric compounds and elimination of the matrix effect was demonstrated by analyzing flavor mixtures. With the merits of fast separation, soft ionization and high detection sensitivity, satisfactory effects in the 2D analysis were achieved, despite the relatively low chromatographic resolution of MCC. As a result, three isomers, eucalyptol, L-menthone and linalool, in a flavor mixture were successfully categorized within 90 s, and the matrix effect caused by solvent ethanol was significantly eliminated as well. The limits of detection (LODs) down to sub-ppbv level were achieved for the investigated five flavor compounds without any enrichment process, and an excellent repeatability was obtained with the relative standard deviations (RSDs) of signal intensities <= 5%. The MCC-HPPI-TOFMS system was preliminarily applied for rapid and online analysis of flavor compounds in(t)he exhaled gas of a volunteer after mouth rinsing with a gargle product. The rapid changes of the three flavor compounds, as well as the steady endogenous metabolite acetone, in the exhaled gas were successfully determined with a time-resolution of only 1.5 min.
WOS关键词SINGLE-PHOTON IONIZATION ; SOLID-PHASE MICROEXTRACTION ; ION MOBILITY SPECTROMETRY ; VACUUM-ULTRAVIOLET LAMP ; HUMAN URINE ; TOF-MS ; GAS ; QUANTIFICATION ; GC ; METABOLITES
资助项目National Natural Science Foundation of China[21675155] ; National Natural Science Foundation of China[21605142]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000471084300005
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/175790]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Hua, Lei; Li, Haiyang
作者单位1.Henan Prov Med Instrument Testing Inst, 79 Xiongerhe Rd, Zhengzhou 450018, Henan, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Xuan,Hua, Lei,Jiang, Jichun,et al. Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds[J]. TALANTA,2019,201:33-39.
APA Chen, Xuan,Hua, Lei,Jiang, Jichun,Hu, Fan,Wan, Ningbo,&Li, Haiyang.(2019).Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds.TALANTA,201,33-39.
MLA Chen, Xuan,et al."Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds".TALANTA 201(2019):33-39.

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来源：大连化学物理研究所

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