effectsofniaoduqingparticles尿毒清颗粒ondelayingprogressionofrenaldysfunctionaposttrialopenlabelfollowupstudy
文献类型：期刊论文
| 作者 | ZHENG Ying24; WANG Niansong23; LIU Yuning22; HE Liqun21; JIAN Guihua23; LIU Xusheng20; NI Zhaohui19; CHENG Xiaohong18; LIN Hongli17; ZHOU Wenhua16 |
| 刊名 | 中国结合医学杂志英文版
 |
| 出版日期 | 2019-01-01 |
| 卷号 | 025期号:003页码:168 |
| ISSN号 | 1672-0415 |
| 英文摘要 | Objective:To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^-1·1.73 m^-2, respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^-1·1.73 m^-2, respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^-1·1.73 m^-2 per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function. |
| 语种 | 英语 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/177780]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.北京大学 2.山东大学 3.南京医科大学 4.Department of Nephrology,Guang'anmen Hospital of China Academy of Traditional Chinese Medical Sciences 5.Department of Nephrology,Beijing Friendship Hospital,Capital Medical University 6.Department of Nephrology,Guangdong General Hospital,Guangdong Academy of Medical Sciences 7.Department of Nephrology-Japan Friendship Hospital 8.Department of Nephrology,Xiyuan Hospital Academy of Chinese Medical Sciences 9.山西医科大学 10.Department of Nephrology,University of Electronic Science and Technology,Sichuan Academy of Sciences and Sichuan Provincial People's Hospital |
| 推荐引用方式 GB/T 7714 | ZHENG Ying,WANG Niansong,LIU Yuning,等. effectsofniaoduqingparticles尿毒清颗粒ondelayingprogressionofrenaldysfunctionaposttrialopenlabelfollowupstudy[J]. 中国结合医学杂志英文版,2019,025(003):168. |
| APA | ZHENG Ying.,WANG Niansong.,LIU Yuning.,HE Liqun.,JIAN Guihua.,...&CHEN Xiangmei.(2019).effectsofniaoduqingparticles尿毒清颗粒ondelayingprogressionofrenaldysfunctionaposttrialopenlabelfollowupstudy.中国结合医学杂志英文版,025(003),168. |
| MLA | ZHENG Ying,et al."effectsofniaoduqingparticles尿毒清颗粒ondelayingprogressionofrenaldysfunctionaposttrialopenlabelfollowupstudy".中国结合医学杂志英文版 025.003(2019):168. |
入库方式： OAI收割
来源：大连化学物理研究所
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