theseparationandenrichmentofglycoproteinsorglycopeptidesbasedonnanoparticles
文献类型：期刊论文
| 作者 | Ding P(丁鹏)2; Chen X(陈掀)2; Li XL(李秀玲)1; Qing GY(卿光焱)2; Sun TL(孙涛垒)2; Liang XM(梁鑫淼)1 |
| 刊名 | progressinchemistry
 |
| 出版日期 | 2015-01-01 |
| 卷号 | 27期号:11页码:1628 |
| ISSN号 | 1005-281X |
| 英文摘要 | As one of the most important post-translational modifications, protein glycosylation has a significant effect on the structures and functions of proteins. Many low-abundance endogenous glycoproteins/glycopeptides in the serum or tissue extracts are biomarkers with higher clinical sensitivity and specificity, which could provide valuable information to explore the pathogenesis of many diseases, discover disease biomarkers and develop proteins based new drugs. However, it is still a great challenge for glycoproteomics to selectively separate and enrich the glycoproteins/glycopeptides from the complex biological samples due to their extremely low concentrations. Nanoparticle materials have been attracted much attention in the separation and enrichment of glycoproteins/glycopeptides due to their large surface to volume ratio, numerous affinity sites and unique structures. In this work, the recent progress for the separation and enrichment of glycoproteins/glycopeptides based on the nanoparticles, including gold, SiO2, TiO2, nanodiamond and polymer nanoparticles are reviewed. Finally, the challenges and prospects for the methods of the separation and enrichment of glycoproteins/glycopeptides are briefly proposed. |
| 资助项目 | [National Natural Science Foundation of China] ; [Major State Basic Research Development Program of China (973 Program)] |
| 语种 | 英语 |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/178287]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.中国科学院大连化学物理研究所 2.武汉理工大学 |
| 推荐引用方式 GB/T 7714 | Ding P,Chen X,Li XL,et al. theseparationandenrichmentofglycoproteinsorglycopeptidesbasedonnanoparticles[J]. progressinchemistry,2015,27(11):1628. |
| APA | 丁鹏,陈掀,李秀玲,卿光焱,孙涛垒,&梁鑫淼.(2015).theseparationandenrichmentofglycoproteinsorglycopeptidesbasedonnanoparticles.progressinchemistry,27(11),1628. |
| MLA | 丁鹏,et al."theseparationandenrichmentofglycoproteinsorglycopeptidesbasedonnanoparticles".progressinchemistry 27.11(2015):1628. |
入库方式： OAI收割
来源：大连化学物理研究所
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