Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study
文献类型：期刊论文
| 作者 | Sun, Lei5; Xu, Jiliang5; Sun, Zihuan5; Zheng, Fang2; Liu, Chun5; Wang, Chao5; Hu, Xiaoye3 ; Xia, Lunguo1; Liu, Zhou4; Xia, Rong5
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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| 出版日期 | 2018 |
| 卷号 | 13页码:6769-6777 |
| 关键词 | Porphyromonas gingivalis tetracycline TiO2 nanotubes mouse bone marrow stromal cells antibacterial drug release |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S175865 |
| 通讯作者 | Xia, Rong(xiarongah@hotmail.com) |
| 英文摘要 | Background: Titanium dioxide (TiO2) nanotubes are often used as carriers for loading materials such as drugs, proteins, and growth factors. Materials and methods: In this study, we loaded tetracycline onto TiO2 nanotubes to demonstrate its antibacterial properties and biocompatibility. The two-layered anodic TiO2 nanotubes with a honeycomb-like porous structure were fabricated by using a two-step anodization, and they were loaded with tetracycline by using a simplified lyophilization method and vacuum drying. Their physical properties, such as chemical compositions, wettability, and surface morphologies of the different samples, were observed and measured by X-ray photoelectron spectroscopy (XPS), contact angle measurement, and scanning electron microscopy (SEM). The in vitro growth behaviors of mouse bone marrow stromal cells (BMSCs) on these substrates were investigated. Results: The TiO2 nanotube (NT) substrates and the tetracycline-loaded TiO2 nanotube (NT-T) substrates revealed a crucial potential for promoting the adhesion, proliferation, and differentiation of BMSCs. Similarly, the NT-T substrates displayed a sudden release of tetracycline in the first 15 minutes of their administration, and the release tended to be stable 90 minutes later. The antibacterial performances of the prepared substrates were assessed with Porphyromonas gingivalis. The result showed that NT and NT-T substrates had antibacterial capacities. Conclusion: Overall, this research provides a promising method with potential for clinical translation by allowing local slow release of antimicrobial compounds by loading them onto constructed nanotubes. |
| WOS关键词 | PERI-IMPLANT DISEASES ; TITANIA NANOTUBES ; BIOFILM ; LYOPHILIZATION ; NANOPARTICLES ; ANTIBIOTICS ; CONSENSUS ; ARRAYS |
| 资助项目 | Natural Science Foundation of Anhui Province[1508085MH156] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000448150900001 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 资助机构 | Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/39762]  |
| 专题 | 合肥物质科学研究院_中科院固体物理研究所 |
| 通讯作者 | Xia, Rong |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthodont, Coll Stomatol,Sch Med, Shanghai, Peoples R China 2.Univ Sci & Technol China, Dept Math, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei, Anhui, Peoples R China 4.Anhui Med Univ, Dept Lab Med, Affiliated Hosp 2, Hefei, Anhui, Peoples R China 5.Anhui Med Univ, Dept Stomatol, Affiliated Hosp 2, 678 Furong Rd, Hefei 230032, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Lei,Xu, Jiliang,Sun, Zihuan,et al. Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2018,13:6769-6777. |
| APA | Sun, Lei.,Xu, Jiliang.,Sun, Zihuan.,Zheng, Fang.,Liu, Chun.,...&Xia, Rong.(2018).Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study.INTERNATIONAL JOURNAL OF NANOMEDICINE,13,6769-6777. |
| MLA | Sun, Lei,et al."Decreased Porphyromonas gingivalis adhesion and improved biocompatibility on tetracycline-loaded TiO2 nanotubes: an in vitro study".INTERNATIONAL JOURNAL OF NANOMEDICINE 13(2018):6769-6777. |
入库方式： OAI收割
来源：合肥物质科学研究院
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