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The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis

文献类型：期刊论文

作者Cheng, Wei2; Wang, Hongzhi3; Yuan, Juanjuan1; Cheng, Ziwei2; Xing, Dongwei2; Zhang, Minguang2
刊名BIOMED RESEARCH INTERNATIONAL
出版日期2018
页码10
ISSN号2314-6133
DOI10.1155/2018/3429261
通讯作者Xing, Dongwei(xdw021@163.com) ; Zhang, Minguang(mgzhang09@163.com)
英文摘要Background. Recent several studies have showed that the nanog overexpression leads to poor prognosis in some kinds of cancer including hepatocellular carcinoma and gastrointestinal luminal cancer. However, the correlations between prognosis and clinic-pathological features and nanog overexpression in lung cancer are still not well-known. Thus, we performed a meta-analysis to evaluate the role of nanog in lung cancer. Methods. An electronic retrieval for related studies was conducted in PubMed, Cochrane Library, Web of Science, EMBASE databases, Chinese CNKI, and the Chinese Wan Fang database up to May 2018. The relationships between nanog overexpression and overall survival (OS) and disease-free survival (DFS) as well as clinic-pathological features in lung cancer were investigated. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by STATA12. Results. 11 studies containing 1422 patients were identified in our meta-analysis. The overexpression of nanog showed decreased OS (HR = 1.83, 95% CI = 1.49-2.25, P 0.001) and DFS (HR = 1.86, 95% CI = 1.2-2.9, P = 0.006). Moreover, overexpression of nanog was significantly related to differentiation (OR = 4.17, 95% CI = 2.17-6.43, P 0.001), lymph node metastasis (OR = 1.76, 95% CI = 1.06-2.91, P = 0.028) and tumor size (OR = 1.93, 95% CI = 1.17-3.20, P = 0.010), and no correlation with T stage, TNM, stage, and gender. Conclusions. Our results suggested that nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased OS and DFS for lung cancer.
WOS关键词STEM-CELLS ; STATISTICS ; EXPRESSION ; MARKER
资助项目National Natural Science Foundation of China[81673743]
WOS研究方向Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000453720300001
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/41140]  
专题中国科学院合肥物质科学研究院
通讯作者Xing, Dongwei; Zhang, Minguang
作者单位1.Anhui Med Univ, Peoples Hosp Hefei 2, Hefei Hosp, Hefei 230011, Anhui, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China
3.Chinese Acad Sci, Canc Hosp, Hefei 230011, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Wei,Wang, Hongzhi,Yuan, Juanjuan,et al. The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2018:10.
APA Cheng, Wei,Wang, Hongzhi,Yuan, Juanjuan,Cheng, Ziwei,Xing, Dongwei,&Zhang, Minguang.(2018).The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis.BIOMED RESEARCH INTERNATIONAL,10.
MLA Cheng, Wei,et al."The Prognostic Value of Nanog Overexpression in Lung Cancer: A Meta-Analysis".BIOMED RESEARCH INTERNATIONAL (2018):10.

入库方式： OAI收割

来源：合肥物质科学研究院

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