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Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice

文献类型：期刊论文

作者Tian, Xiaofei1,2; Wang, Ze1,3; Zhang, Lei1; Xi, Chuanying1; Pi, Li1; Qi, Ziping1; Lu, Qingyou1,3,4; Zhang, Xin1,2
刊名CHINESE PHYSICS B
出版日期2018-11-01
卷号27期号:11页码:10
关键词static magnetic field (SMF) high magnetic field (MF) tumor magnetic field gradient
ISSN号1674-1056
DOI10.1088/1674-1056/27/11/118703
通讯作者Lu, Qingyou(qxl@ustc.edu.cn) ; Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要Since high magnetic field (MF) intensity can improve the image quality and reduce magnetic resonance imaging (MRI) acquisition time, the field intensity of MRIs has continued to increase over the past few decades. Although MRIs in most current hospitals are 0.5 T-3 T, there are preclinical studies have been carried out using 9.4 T MRI, and engineers are also putting efforts on building MRIs with even higher MFs. However, the accompanied safety issue of high-field MRIs is an emergent question to address before their clinical applications. In the meantime, the static magnetic field (SMF) has been shown to inhibit tumor growth in previous studies. Here, we investigated both the safety issue and the anti-tumor potentials of 3.7 T-24.5 T SMFs on GIST-TI gastrointestinal stromal tumor-bearing nude mice. We followed up the mice three weeks after their exposure to high SMF and found that none of the mice died or had severe organ damage, except for slightly decreased food intake, weight gain, and liver function. Moreover, the tumor growth was inhibited by 3.7 T-24.5 T SMFs (up to similar to 54%). It is interesting that the effects are more dependent on MF gradient than intensities, and for the same gradient and intensity, mice responded differently to hypogravity and hypergravity conditions. Therefore, our study not only demonstrated the safeness of high SMFs up to 24.5 T on mice but also revealed their anti-tumor potentials in the future.
WOS关键词ORIENTATION ; RESONANCE ; CELLS ; ERYTHROCYTES ; EXPOSURE ; SODIUM ; GLIOMA ; MRI
资助项目National Key R&D Program of China[2016YFA0400900] ; National Key R&D Program of China[2017YFA0402903] ; National Natural Science Foundation of China[U1532151] ; National Natural Science Foundation of China[51627901] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology[2016FXCX004] ; Hefei Science Center, CAS[2016HSC-IU007] ; CASHIPS Director's Fund[YZJJ201704]
WOS研究方向Physics
语种英语
WOS记录号WOS:000450997500003
出版者IOP PUBLISHING LTD
资助机构National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science, Technology ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; Hefei Science Center, CAS ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund ; CASHIPS Director's Fund
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/40430]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Lu, Qingyou; Zhang, Xin
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
4.Anhui Prov Key Lab Condensed Matter Phys Extreme, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Tian, Xiaofei,Wang, Ze,Zhang, Lei,et al. Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice[J]. CHINESE PHYSICS B,2018,27(11):10.
APA Tian, Xiaofei.,Wang, Ze.,Zhang, Lei.,Xi, Chuanying.,Pi, Li.,...&Zhang, Xin.(2018).Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice.CHINESE PHYSICS B,27(11),10.
MLA Tian, Xiaofei,et al."Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice".CHINESE PHYSICS B 27.11(2018):10.

入库方式： OAI收割

来源：合肥物质科学研究院

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