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  2. 合肥物质科学研究院
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  4. 中科院强磁场科学中心
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

文献类型：期刊论文

作者Gong, Hongri1,2; Li, Jun3,4; Xu, Ao1,2,5; Tang, Yanting1,2; Ji, Wenxin5,6; Gao, Ruogu5,6; Wang, Shuhui3,4; Yu, Lu7; Tian, Changlin7,8,9; Li, Jingwen10
刊名SCIENCE
出版日期2018-11-30
卷号362期号:6418页码:1020-+
ISSN号0036-8075
DOI10.1126/science.aat8923
通讯作者Sun, Fei(feisun@ibp.ac.cn) ; Wang, Quan(wangq@ibp.ac.cn) ; Rao, Zihe(raozh@tsinghua.edu.cn)
英文摘要We report a 3.5-angstrom-resolution cryo-electron microscopy structure of a respiratory supercomplex isolated from Mycobacterium smegmatis. It comprises a complex III dimer flanked on either side by individual complex IV subunits. Complex III and IV associate so that electrons can be transferred from quinol in complex III to the oxygen reduction center in complex IV by way of a bridging cytochrome subunit. We observed a superoxide dismutase-like subunit at the periplasmic face, which may be responsible for detoxification of superoxide formed by complex III. The structure reveals features of an established drug target and provides a foundation for the development of treatments for human tuberculosis.
WOS关键词CYTOCHROME-C-OXIDASE ; CU,ZN SUPEROXIDE-DISMUTASE ; BEAM-INDUCED MOTION ; PARACOCCUS-DENITRIFICANS ; CRYSTAL-STRUCTURE ; SUPRAMOLECULAR ORGANIZATION ; CORYNEBACTERIUM-GLUTAMICUM ; TERMINAL OXIDASE ; COMPLEX ; TUBERCULOSIS
资助项目National Key Research and Development Program of China[2017YFC0840300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB08020200] ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project)[2014CB542800] ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project)[2014CBA02003] ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project)[2014CB910700] ; National Natural Science Foundation of China[813300237] ; National Natural Science Foundation of China[81520108019]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号WOS:000451609000036
资助机构National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; State Key Development Program for Basic Research of the Ministry of Science and Technology of China (973 Project) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/40506]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Sun, Fei; Wang, Quan; Rao, Zihe
作者单位1.Nankai Univ, Coll Life Sci, Tianjin 300353, Peoples R China
2.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300353, Peoples R China
3.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China
5.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
8.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China
9.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
10.Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, South Parks Rd, Oxford OX1 3QZ, England
推荐引用方式
GB/T 7714		 Gong, Hongri,Li, Jun,Xu, Ao,et al. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex[J]. SCIENCE,2018,362(6418):1020-+.
APA Gong, Hongri.,Li, Jun.,Xu, Ao.,Tang, Yanting.,Ji, Wenxin.,...&Rao, Zihe.(2018).An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.SCIENCE,362(6418),1020-+.
MLA Gong, Hongri,et al."An electron transfer path connects subunits of a mycobacterial respiratory supercomplex".SCIENCE 362.6418(2018):1020-+.

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来源：合肥物质科学研究院

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