Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
文献类型：期刊论文
| 作者 | Zha, Meng1; Tao, Qingping1,2; Li, Jun3; Tian, Xiaofei1,2; Feng, Shuang1,2; Liao, Zhongcai3; Fang, Zhicai3; Zhang, Xin1,4
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| 刊名 | ELECTROMAGNETIC BIOLOGY AND MEDICINE
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| 出版日期 | 2018 |
| 卷号 | 37期号:4页码:192-201 |
| 关键词 | Rotating magnetic field (RMF) Low frequency Rotating magnetic field (LF-RMF) moderate intensity low frequency rotating magnetic field breast cancer gastrointestinal stromal tumor |
| ISSN号 | 1536-8378 |
| DOI | 10.1080/15368378.2018.1506989 |
| 通讯作者 | Zhang, Xin(xinzhang@hmfl.ac.cn) |
| 英文摘要 | Moderate intensity low frequency rotating magnetic field (LF-RMF) has been shown to inhibit melanoma, liver and lung cancer growth in mice. However, its effects on other types of cancers have not been investigated in vivo. Here, we show that 0-0.15T moderate intensity 4.2Hz LF-RMF can inhibit tumor growth in mice bearing MDA-MB231 and MCF7 human breast cancer cells by over 30%. In contrast, the human gastrointestinal stromal tumor GIST-T1 growth was not inhibited by LF-RMF. In all RMF treatments, there were no apparent adverse effects on mice organs, body weight or water/food consumptions. However, the alanine aminotransferase (ALT) level was decreased in LF-RMF-treated mice bearing MCF7 and GIST-T1 cells, which indicated alleviated liver damage. Therefore, our study shows that moderate intensity LF-RMF might be a safe physical method that has clinical potentials to be used to inhibit breast cancer growth in the future. |
| WOS关键词 | ALANINE AMINOTRANSFERASE LEVELS ; HEPATOCELLULAR-CARCINOMA ; MECHANICAL DESTRUCTION ; ANTITUMOR EFFICACY ; TRANSDUCER ARRAYS |
| 资助项目 | National Natural Science Foundation of China[U1532151] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX004] ; Hefei Science Center CAS[2016HSC-IU007] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000452841800003 |
| 出版者 | TAYLOR & FRANCIS INC |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS ; Hefei Science Center CAS |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/41137]  |
| 专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei, Peoples R China 3.Zhejiang Heye Hlth Technol Co Ltd, Anji, Peoples R China 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zha, Meng,Tao, Qingping,Li, Jun,et al. Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice[J]. ELECTROMAGNETIC BIOLOGY AND MEDICINE,2018,37(4):192-201. |
| APA | Zha, Meng.,Tao, Qingping.,Li, Jun.,Tian, Xiaofei.,Feng, Shuang.,...&Zhang, Xin.(2018).Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice.ELECTROMAGNETIC BIOLOGY AND MEDICINE,37(4),192-201. |
| MLA | Zha, Meng,et al."Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice".ELECTROMAGNETIC BIOLOGY AND MEDICINE 37.4(2018):192-201. |
入库方式： OAI收割
来源：合肥物质科学研究院
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