中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 技术生物与农业工程研究所
Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

文献类型：期刊论文

作者Chen, Biao1,2; Zhang, Yajun2,3; Yang, Yaning1,2; Chen, Shaopeng2,3; Xu, An1,2,3; Wu, Lijun1,2,3,4; Xu, Shengmin2,3
刊名NANOMEDICINE
出版日期2018-08-01
卷号13期号:16页码:2067-2082
关键词anticancer effects radiosensitivity silver nanoparticles telomerase telomere
ISSN号1743-5889
DOI10.2217/nnm-2018-0036
通讯作者Wu, Lijun(ljw@ipp.ac.cn) ; Xu, Shengmin(shmxu@mail.ustc.edu.cn)
英文摘要Aim: To investigate the possible mechanisms of telomerase and telomere underlying the anticancer effects of silver nanoparticles (AgNPs). Materials & methods: 25nm polyvinylpyrrolidone-coated AgNPs were used. The telomerase activity and telomere function were evaluated. The anticancer effects of AgNPs were gauged with cell viability assay under different statement of telomerase and telomere. Results & conclusion: AgNPs could inhibit telomerase activity and lead to telomere shortening and dysfunction. Overexpression of telomerase attenuated the anticancer activity of AgNPs, whereas downregulation of telomerase activity or dysfunction of the telomere enhanced the cytotoxicity of AgNPs in HeLa cells. Our findings provided strong evidence that the anticancer effects of AgNPs were mediated via interference with the telomerase/telomere.
WOS关键词G-QUADRUPLEX ; DNA-DAMAGE ; CANCER-CELLS ; GENE-EXPRESSION ; HEPG2 CELLS ; HISTONE H3 ; AUTOPHAGY ; SENESCENCE ; APOPTOSIS ; PROMOTES
资助项目National Basic Research 973 Program[2014CB932002] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14030502] ; National Natural Science Foundation of China[31670860] ; National Natural Science Foundation of China[31470829] ; Natural Science Foundation of Anhui Province[1808085QB37]
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000446402000008
出版者FUTURE MEDICINE LTD
资助机构National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; National Basic Research 973 Program ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/39575]  
专题合肥物质科学研究院_技术生物与农业工程研究所
通讯作者Wu, Lijun; Xu, Shengmin
作者单位1.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
3.Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Anhui, Peoples R China
4.Anhui Univ, Inst Phys & Informat Technol, Hefei 230601, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Biao,Zhang, Yajun,Yang, Yaning,et al. Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects[J]. NANOMEDICINE,2018,13(16):2067-2082.
APA Chen, Biao.,Zhang, Yajun.,Yang, Yaning.,Chen, Shaopeng.,Xu, An.,...&Xu, Shengmin.(2018).Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects.NANOMEDICINE,13(16),2067-2082.
MLA Chen, Biao,et al."Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects".NANOMEDICINE 13.16(2018):2067-2082.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。