Enantioselective Synthesis of (-)-Stemoamide
文献类型：期刊论文
| 作者 | Mi XW(米贤伟) ; Wang Y(王燕) ; Zhu LL(朱莉莉) ; Wang RX(王任小) ; Hong R(洪然) |
| 刊名 | Synthesis
 |
| 出版日期 | 2012 |
| 卷号 | 44期号:22页码:3432-3440 |
| ISSN号 | 0039-7881 |
| 其他题名 | 百部酰胺的对映选择性合成 |
| 通讯作者 | 洪然 |
| 英文摘要 | An enantioselective synthesis of (-)-stemoamide is presented. Noyori's ruthenium complex catalyzed asymmetric transfer hydrogenation of an alkynone delivered the (S)-C8 stereogenic center in 97.7% ee. An iron(III) chloride promoted and bioinspired N-iminium ion cyclization afforded a 3: 1 ratio of two diastereomers in favor of the cis-isomer. The diastereomeric ratio was enriched to 50: 1 by a silver-catalyzed cycloisomerization. The subsequent dynamic ruthenium-catalyzed CO-insertion reaction secured an enantioselective total synthesis of (-)-stemoamide in 18% overall yield with high optical purity. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1055/s-0032-1317499 |
| 语种 | 英语 |
| WOS记录号 | WOS:000312001900003 |
| 公开日期 | 2013-08-29 |
| 源URL | [http://202.127.28.38/handle/331003/28647]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Mi XW,Wang Y,Zhu LL,et al. Enantioselective Synthesis of (-)-Stemoamide[J]. Synthesis,2012,44(22):3432-3440. |
| APA | 米贤伟,王燕,朱莉莉,王任小,&洪然.(2012).Enantioselective Synthesis of (-)-Stemoamide.Synthesis,44(22),3432-3440. |
| MLA | 米贤伟,et al."Enantioselective Synthesis of (-)-Stemoamide".Synthesis 44.22(2012):3432-3440. |
入库方式： OAI收割
来源：上海有机化学研究所
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