Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs
文献类型：期刊论文
| 作者 | Chen ZH(陈增浩) ; Wang RW(王若文) ; Qing FL(卿凤翎) |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2012 |
| 卷号 | 53期号:17页码:2171-2176 |
| ISSN号 | 0040-4039 |
| 其他题名 | SGLT2抑制剂的合成和生物评价: gem-二氟亚甲基Dapagliflozin类似物 |
| 通讯作者 | 卿凤翎 |
| 英文摘要 | Dapagliflozin is currently the most advanced SGLT2 inhibitor, which has been used in Phase III clinical trials for treatment of diabetes. Here we describe the design and synthesis of Dapagliflozin analogs modified with gem-difluoromethylene group. Their biological evaluation of in vitro inhibitory activity against human SGLT2 showed that some of the analogs with CF2 at C-4 are better SGLT2 inhibitors compared with Dapagliflozin. (c) 2012 Elsevier Ltd. All rights reserved. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2012.02.062 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302587800007 |
| 公开日期 | 2013-08-23 |
| 源URL | [http://202.127.28.38/handle/331003/28249]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen ZH,Wang RW,Qing FL. Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs[J]. Tetrahedron Lett.,2012,53(17):2171-2176. |
| APA | 陈增浩,王若文,&卿凤翎.(2012).Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs.Tetrahedron Lett.,53(17),2171-2176. |
| MLA | 陈增浩,et al."Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs".Tetrahedron Lett. 53.17(2012):2171-2176. |
入库方式： OAI收割
来源：上海有机化学研究所
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