Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A
文献类型：期刊论文
| 作者 | Chen ZH(陈增浩) ; Wang BL(王炳林) ; Andrew J. Kale ; Bradley S. Moore ; Wang RW(王若文) ; Qing FL(卿凤翎) |
| 刊名 | J. Fluor. Chem.
 |
| 出版日期 | 2012 |
| 卷号 | 136页码:12-19 |
| ISSN号 | 0022-1139 |
| 其他题名 | 空间位阻醛和含氟合成子的偶联反应: salinosporamide A.的立体选择性合成 |
| 通讯作者 | 卿凤翎 |
| 英文摘要 | Salinosporamide A is an irreversible inhibitor of the beta-subunits of the 20S proteasome. Its C-5 cyclohexenyl moiety is the key to its affinity and potency as an anticancer agent. Here we describe the synthesis of C-5 difluoromethylated and trifluoromethylated analogues of salinosporamide A and their biological evaluation as proteasome inhibitors against purified yeast 20S proteasome. The synthetic strategy featured the stereoselective coupling reaction of sterically hindered aldehyde 3 with fluorinated organolithium reagents. (C) 2012 Elsevier B.V. All rights reserved. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.jfluchem.2012.01.003 |
| 语种 | 英语 |
| WOS记录号 | WOS:000302976900003 |
| 公开日期 | 2013-08-23 |
| 源URL | [http://202.127.28.38/handle/331003/28263]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen ZH,Wang BL,Andrew J. Kale,et al. Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A[J]. J. Fluor. Chem.,2012,136:12-19. |
| APA | 陈增浩,王炳林,Andrew J. Kale,Bradley S. Moore,王若文,&卿凤翎.(2012).Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A.J. Fluor. Chem.,136,12-19. |
| MLA | 陈增浩,et al."Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A".J. Fluor. Chem. 136(2012):12-19. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。