A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery
文献类型：期刊论文
| 作者 | Huang YJ(黄银娟)1; Liu MZ(刘明柱)1; Chen JC(陈久存)1; Gao CM(高春美)1; Gong QY(龚秋雨)2
|
| 刊名 | European Polymer Journal
 |
| 出版日期 | 2012 |
| 卷号 | 48期号:10页码:1734-1744 |
| 关键词 | 2-(Dimethylamino) ethyl methacrylate 3-Acrylamide phenylboronic acid Hydrogels Triple-responsive Fe3O4 Targeted |
| ISSN号 | 0014-3057 |
| 通讯作者 | 刘明柱 |
| 英文摘要 | In this work, Fe3O4/poly(3-acrylamidephenylboronic acid-co-(2-dimethylamino) ethyl methacrylate) (Fe3O4/P(AAPBA-co-DMAEMA)) hydrogels possessing magnetic and triple-responsive properties and semi-interpenetrated by β-cyclodextrin-epichlorohydrin (β-CD-EPI) were prepared via radical polymerization. The characteristics of the materials have been investigated by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM). The swelling measurements and the application of Fe3O4/P(AAPBA-co-DMAEMA)/(β-CD-EPI) hydrogels in controlled release of drug were also investigated. It was found that the magnetic hydrogels exhibit swelling behaviors affected by pH, temperature, glucose concentration and magnetic field, and have porous morphologies, superparamagnetism. Moreover, the hydrogels possess targeting and could control the release of quercetin by adjusting pH value, temperature, glucose concentration and magnetic field. |
| 学科主题 | 材料科学与物理化学 |
| 收录类别 | SCI |
| 资助信息 | the Special Doctorial Program Funds of the Education of China (Grant No.: 20090211110004);Gansu Province Project of Science and Technologies (Grant No.: 0804WCGA130) |
| 语种 | 英语 |
| WOS记录号 | WOS:000310110300009 |
| 公开日期 | 2013-07-12 |
| 源URL | [http://210.77.64.217/handle/362003/3337]  |
| 专题 | 兰州化学物理研究所_固体润滑国家重点实验室 |
| 作者单位 | 1.Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China 2.Key Laboratory of Solid Lubrication, Chinese Academy of Sciences, Lanzhou Institute of Chemical Physics, Lanzhou 730000, PR China |
| 推荐引用方式 GB/T 7714 | Huang YJ,Liu MZ,Chen JC,et al. A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery[J]. European Polymer Journal,2012,48(10):1734-1744. |
| APA | Huang YJ,Liu MZ,Chen JC,Gao CM,&Gong QY.(2012).A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery.European Polymer Journal,48(10),1734-1744. |
| MLA | Huang YJ,et al."A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery".European Polymer Journal 48.10(2012):1734-1744. |
入库方式： OAI收割
来源：兰州化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。