Plasma lipidomic signatures of spontaneous obese rhesus monkeys
文献类型：期刊论文
| 作者 | Wang, JL; Zhang, LQ; Xiao, RY; Li, YH; Liao, SS; Zhang, ZG; Yang, WH; Liang, B |
| 刊名 | LIPIDS IN HEALTH AND DISEASE
 |
| 出版日期 | 2019 |
| 卷号 | 18 |
| ISSN号 | 1476-511X |
| 英文摘要 | BackgroundObesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D). The underlying mechanisms linking obesity to metabolic diseases are still less understandable.MethodsPreviously, we screened a group of spontaneously obese rhesus monkeys. Here, we performed a plasma lipidomic analysis of normal and obese monkeys using gas chromatography/mass spectroscopy (GC/MS) and ultra-high performance liquid chromatography/mass spectroscopy (UPLC/MS).ResultsIn total, 143 lipid species were identified, quantified, and classified into free fatty acids (FFA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylglycerol (PG), lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), and sphingomyelin (SM). Data analysis showed that the obese monkeys had increased levels of fatty acids palmitoleic acid (C16:1) and arachidonic acid (C20:4), FFA especially palmitic acid (C16:0), as well as certain PC species and SM species. Surprisingly, the plasma level of LPA-C16:0 was approximately four-fold greater in the obese monkeys. Conversely, the levels of most PE species were obviously reduced in the obese monkeys.ConclusionCollectively, our work suggests that lipids such as FFA C16:0 and 16:0-LPA may be potential candidates for the diagnosis and study of obesity-related diseases. |
| 语种 | 英语 |
| 源URL | [http://ir.kiz.ac.cn:8080/handle/152453/12531]  |
| 专题 | 昆明动物研究所_脂类代谢与疾病 |
| 推荐引用方式 GB/T 7714 | Wang, JL,Zhang, LQ,Xiao, RY,et al. Plasma lipidomic signatures of spontaneous obese rhesus monkeys[J]. LIPIDS IN HEALTH AND DISEASE,2019,18. |
| APA | Wang, JL.,Zhang, LQ.,Xiao, RY.,Li, YH.,Liao, SS.,...&Liang, B.(2019).Plasma lipidomic signatures of spontaneous obese rhesus monkeys.LIPIDS IN HEALTH AND DISEASE,18. |
| MLA | Wang, JL,et al."Plasma lipidomic signatures of spontaneous obese rhesus monkeys".LIPIDS IN HEALTH AND DISEASE 18(2019). |
入库方式： OAI收割
来源：昆明动物研究所
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