Molecular basis for heat desensitization of TRPV1 ion channels
文献类型：期刊论文
| 作者 | Luo, L; Wang, YF; Li, BW; Xu, LZ; Kamau, PM; Zheng, J; Yang, F; Yang, SL; Lai, R |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2019 |
| 卷号 | 10 |
| ISSN号 | 2041-1723 |
| 英文摘要 | The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. We further show that knock-in mice expressing pV1 sensed heat normally but suffered scald damages in a hot environment. Our findings suggest that Dh evolved late during evolution as a protective mechanism and a delicate balance between Ah and Dh is crucial for mammals to sense and respond to noxious heat. |
| 语种 | 英语 |
| 源URL | [http://ir.kiz.ac.cn:8080/handle/152453/12446]  |
| 专题 | 昆明动物研究所_动物毒素室 |
| 推荐引用方式 GB/T 7714 | Luo, L,Wang, YF,Li, BW,et al. Molecular basis for heat desensitization of TRPV1 ion channels[J]. NATURE COMMUNICATIONS,2019,10. |
| APA | Luo, L.,Wang, YF.,Li, BW.,Xu, LZ.,Kamau, PM.,...&Lai, R.(2019).Molecular basis for heat desensitization of TRPV1 ion channels.NATURE COMMUNICATIONS,10. |
| MLA | Luo, L,et al."Molecular basis for heat desensitization of TRPV1 ion channels".NATURE COMMUNICATIONS 10(2019). |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。