Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives
文献类型：期刊论文
| 作者 | Zhang, DF; Xu, M; Bi, R; Yao, YG |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2019 |
| 卷号 | 10期号:2页码:890-901 |
| ISSN号 | 1948-7193 |
| 英文摘要 | Since 2010, the Chinese have become one of the most aged populations in the world, leading to a severe burden of neurodegenerative disorders. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and has a high genetic heritability. In the past two decades, numerous genetic analyses, from linkage analyses and candidate gene studies to genome-wide association studies (GWASs) and next-generation sequencing studies, have identified dozens of AD susceptibility or causal genes. These studies have provided a comprehensive genetic view and contributed to the understanding of the pathological and molecular mechanisms of the disease. However, most of the recognized AD genetic been reported in European populations or populations of European ancestry, and data about the genetics of AD from other populations has been very limited. As China has the largest AD population in the world and because of the remarkable genetic differences between the East and the West, deciphering the genetic basis and molecular mechanism in Chinese patients with AD may add key points to the full characterization of AD. In this review, we present an overview of the current state of AD genetic research in China, with an emphasis on genome-level studies. We also describe the challenges and opportunities for future advances, especially for in-depth collaborations, brain bank construction, and primate animal modeling. There is an urgent need to promote public awareness and increase our collaborations and data sharing. |
| 语种 | 英语 |
| 源URL | [http://ir.kiz.ac.cn:8080/handle/152453/12568]  |
| 专题 | 昆明动物研究所_重大疾病机理的遗传学 |
| 推荐引用方式 GB/T 7714 | Zhang, DF,Xu, M,Bi, R,et al. Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives[J]. ACS CHEMICAL NEUROSCIENCE,2019,10(2):890-901. |
| APA | Zhang, DF,Xu, M,Bi, R,&Yao, YG.(2019).Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives.ACS CHEMICAL NEUROSCIENCE,10(2),890-901. |
| MLA | Zhang, DF,et al."Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives".ACS CHEMICAL NEUROSCIENCE 10.2(2019):890-901. |
入库方式： OAI收割
来源：昆明动物研究所
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