The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau
文献类型：期刊论文
| 作者 | Charati, H; Peng, MS; Chen, W; Yang, XY; Ori, RJ; Aghajanpour-Mir, M; Esmailizadeh, A; Zhang, YP |
| 刊名 | HUMAN GENOMICS
 |
| 出版日期 | 2019 |
| 卷号 | 13 |
| ISSN号 | 1473-9542 |
| 英文摘要 | BackgroundThe ability to digest dietary lactose is associated with lactase persistence (LP) in the intestinal lumen in human. The genetic basis of LP has been investigated in many populations in the world. Iran has a long history of pastoralism and the daily consumption of dairy products; thus, we aim to assess how LP has evolved in the Iranian population. We recruited 400 adult individuals from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus.ResultsThe LP frequency distribution ranged from 0 to 29.9% in the seven Iranian ethnic groups with an average value of 9.8%. The variants, -13910*T and -22018*A, were significantly associated with LP phenotype in Iranians. We found no evidence of hard selective sweep for -13910*T and -22018*A in Persians, the largest ethnic group of Iran. The extremely low frequency of -13915*G in the Iranian population challenged the view that LP distribution in Iran resulted from the demic diffusion, especially mediated by the spread of Islam, from the Arabian Peninsula.ConclusionsOur results indicate the distribution of LP in seven ethnic groups across the Iranian plateau. Soft selective sweep rather than hard selective sweep played a substantial role in the evolution of LP in Iranian populations. |
| 语种 | 英语 |
| 源URL | [http://ir.kiz.ac.cn:8080/handle/152453/12579]  |
| 专题 | 昆明动物研究所_分子进化基因组学 |
| 推荐引用方式 GB/T 7714 | Charati, H,Peng, MS,Chen, W,et al. The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau[J]. HUMAN GENOMICS,2019,13. |
| APA | Charati, H.,Peng, MS.,Chen, W.,Yang, XY.,Ori, RJ.,...&Zhang, YP.(2019).The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau.HUMAN GENOMICS,13. |
| MLA | Charati, H,et al."The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau".HUMAN GENOMICS 13(2019). |
入库方式： OAI收割
来源：昆明动物研究所
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