Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti
文献类型：期刊论文
| 作者 | Li, YK; Wu, JY; Li, D; Huang, AQ; Bu, GX; Meng, FY; Kong, FL; Cao, XH; Han, XF; Pan, XF |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 84页码:816-824 |
| ISSN号 | 1050-4648 |
| 英文摘要 | Schizothorax prenatal (S. prencmd), an important species of economical fish in Southwest China, is susceptible to Aeromonas hydrophila (Ah). To understand the immune response to Ah, the transcriptome profiling of spleen of S. prenanti was analyzed after Ah infection. A total of 6, 213 different expression genes (DEGs) were obtained, including 3, 066 up-regulated DEGs and 3, 147 down-regulated DEGs. These DEGs were annotated by KEGG and GO databases, so that the immune-related DEGs (IRDs) can be identified and classified. Then, the interesting IRDs were screened to build heat map, and the reliability of the transcriptome data was validated by qPCR. In order to clarify the mechanism of signal transduction in the anti-bacterial immunity, the signaling pathway initiated by TLRs was predicted. In this pathway, TLR25 and TLR5 mediate the NF-kappa B and AP-1 signals via MyD88-dependent pathway. Meanwhile, the type I IFN (IFN alpha/beta) induced by IRF1 and IRF3/7 may play an important role in the anti-bacterial immunity. In conclusion, this study preliminarily provides insights into the mechanism of signal transduction after Ah infection in S. prenanti, which contributes to exploring the complex anti-bacterial immunity. |
| 语种 | 英语 |
| 源URL | [http://ir.kiz.ac.cn:8080/handle/152453/12562]  |
| 专题 | 昆明动物研究所_系统进化与生物地理学 |
| 推荐引用方式 GB/T 7714 | Li, YK,Wu, JY,Li, D,et al. Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti[J]. FISH & SHELLFISH IMMUNOLOGY,2019,84:816-824. |
| APA | Li, YK.,Wu, JY.,Li, D.,Huang, AQ.,Bu, GX.,...&Du, XG.(2019).Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti.FISH & SHELLFISH IMMUNOLOGY,84,816-824. |
| MLA | Li, YK,et al."Transcriptome analysis of spleen reveals the signal transduction of toll-like receptors after Aeromonas hydrophila infection in Schizothorax prenanti".FISH & SHELLFISH IMMUNOLOGY 84(2019):816-824. |
入库方式： OAI收割
来源：昆明动物研究所
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