Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
文献类型：期刊论文
| 作者 | Wei Hu; Yue-Mao Shen; Zhi-Yu Li; Xun Li; Yong-Tang Zheng |
| 刊名 | Journal of Medicinal Chemistry
 |
| 出版日期 | 2018-05 |
| 期号 | ~页码:~ |
| DOI | 10.1021/acs.jmedchem.7b01202 |
| 英文摘要 | DNA topoisomerase II (topo II) is an importantenzyme involved in DNA replication, recombination, and repair.Despite the popular applications of topo II inhibitors in cancertherapy, there is still an urgent need to upgrade topo II inhibitors tocope with drug resistance and severe adverse effects. Accordingly,novel topo II catalytic or multitarget topo II inhibitors are gainingmore attention and make it possible to ease the toxic limitations oftopo II poisons. In this review, medicinal chemistry approaches aremainly discussed toward the development of potent topo II inhib-itors with low toxicities. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/12254]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | Yong-Tang Zheng |
| 作者单位 | 1.Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012, Ji’nan, Shandong, P. R. China 2.State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, 27 South Shanda Road, 250100 Ji’nan, Shandong, P. R. China 3.Institute of Criminal Science and Technology, Ji’nan Public Security Bureau, 21 South QiliShan Road, 250000 Ji’nan, Shandong, P. R. China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Science and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Philadelphia, Pennsylvania 19104, United States |
| 推荐引用方式 GB/T 7714 | Wei Hu,Yue-Mao Shen,Zhi-Yu Li,et al. Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.[J]. Journal of Medicinal Chemistry,2018(~):~. |
| APA | Wei Hu,Yue-Mao Shen,Zhi-Yu Li,Xun Li,&Yong-Tang Zheng.(2018).Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches..Journal of Medicinal Chemistry(~),~. |
| MLA | Wei Hu,et al."Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.".Journal of Medicinal Chemistry .~(2018):~. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。