A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage
文献类型：期刊论文
| 作者 | Rose Ombati; Yunfei Wang; Shilong Yang*; Ren Lai*; Canwei Du; Xiancui Lu; Bowen Li; Atunga Nyachieo; Yaxiong Li*; liyaxiong62@aliyun.com |
| 刊名 | Toxicon
 |
| 出版日期 | 2018 |
| 期号 | 48页码:56-63 |
| 关键词 | Wasp Envenomation Membrane Disrupting Toxin Inflammation Edema Tissue Necrosis |
| DOI | 10.1016/j.toxicon.2018.04.011 |
| 英文摘要 | The molecular mechanism of the local hypersensitivity reactions to wasp venom including dermal necrosis remains an enigma regardless of the numerosity of the reported cases. In this study, we discovered a new membrane disrupting toxin, VESCP-M2 responsible for tissue damage symptoms following Vespa mandarinia envenomation. Electrophysiological assays revealed a potent ability of VESCP-M2 to permeate the cell membrane whereas in vivo experiments demonstrated that VESCP-M2 induces edema, pain and dermal necrosis characterized by the presence of morphological and behavioral phenotypes, pro-inflammatory mediators, biomarkers as well as the disruption of dermal tissue. This study presents the molecular mechanism and symptom-related function of VESCP-M2 which may form a basis for prognosis as well as therapeutic interventions. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/12133]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | liyaxiong62@aliyun.com |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 4.Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya PO Box 24481-00502, Karen, Nairobi, Kenya 5.Cardiovascular Surgery Department of Kunming Yan'an Hospital, Kunming 650051, China |
| 推荐引用方式 GB/T 7714 | Rose Ombati,Yunfei Wang,Shilong Yang*,et al. A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage[J]. Toxicon,2018(48):56-63. |
| APA | Rose Ombati.,Yunfei Wang.,Shilong Yang*.,Ren Lai*.,Canwei Du.,...&liyaxiong62@aliyun.com.(2018).A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage.Toxicon(48),56-63. |
| MLA | Rose Ombati,et al."A membrane disrupting toxin from wasp venom underlies the molecular mechanism of tissue damage".Toxicon .48(2018):56-63. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。