Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models
文献类型：期刊论文
| 作者 | Sun YM*1,2; Pan ZJ3; Ma YY2; y.m.s.sun@vu.nl |
| 刊名 | Pharmacology, Biochemistry and Behavior
 |
| 出版日期 | 2017 |
| 卷号 | 159期号:X页码:62-68 |
| 关键词 | Morphine Cpp Entrances To Side Chambers Reward Memory Drug Craving Incubation Of Drug Craving |
| 英文摘要 | In humans, cues associated with the rewarding effect of drugs of abuse induce drug craving and activate drug-associated memories after prolonged abstinence. In animal studies with the self-administration (SA) paradigm, responses to drug-associated cues increase within time after extinction, a phenomenon described as incubation of craving. Conditioned place preference (CPP) is widely used to measure the rewarding effect of drugs and the reward memory thereof. However, little is known whether responses to drug associated cues progressively increase after abstinence from the drugs in the CPP paradigm. To test whether the drug-associated cues could increase specific responses over the abstinence period in the CPP paradigm, we employed the high dose morphine-induced CPP paradigms in rats and tree shrews in the present study. We examined the CPP scores and the entrances to side chambers of the CPP apparatus to check whether they would progressively increase in the CPP paradigms. Twenty-one male adult Sprague-Dawley rats and eight adult male tree shrews were used to establish morphine-induced CPP and another ten rats treated with saline were controls for the rat experiments. After morphine conditioning, rats and tree shrews showed significant higher CPP scores at the first or second post tests than at baseline but then the CPP scores in the abstinence period decreased gradually. The declined CPP scores might due to the repeated exposures or the high doses of morphine used in this study. During the abstinence period, animals with morphine-conditioning experiences entered progressively more times to both side compartments, whereas the number of entrances to side chambers of the saline group in rats had no such significant differences. These findings suggest that progressively increased entrances to the side chambers in the extended abstinence period reflect the incubation of craving in high dose morphine-induced CPP paradigms. Further experiments with lower doses of morphine or other drugs of abuse will be conducted to test whether similar patterns of entrances exist in different species. Also, our data imply that reward memory and drug craving can be distinguished in the CPP paradigm. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11947]  |
| 专题 | 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_认知障碍病理学 |
| 通讯作者 | y.m.s.sun@vu.nl |
| 作者单位 | 1.Department of Molecular and Cellular Neurobiology, Center for Neurogenomics& Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, Netherlands 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Honghe Health Vocational College, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Sun YM*,Pan ZJ,Ma YY,et al. Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models[J]. Pharmacology, Biochemistry and Behavior,2017,159(X):62-68. |
| APA | Sun YM*,Pan ZJ,Ma YY,&y.m.s.sun@vu.nl.(2017).Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models.Pharmacology, Biochemistry and Behavior,159(X),62-68. |
| MLA | Sun YM*,et al."Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models".Pharmacology, Biochemistry and Behavior 159.X(2017):62-68. |
入库方式： OAI收割
来源：昆明动物研究所
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