Genome sequence of a diabetes-prone desert rodent reveals 1 a mutation hotspot around the ParaHox gene cluster
文献类型：期刊论文
| 作者 | Hargreaves AD[1]1; Zhou L2; Li F2; Jansen PG3; Spiga E5; Hansen MT3; Biswas S6; Serikawa K6; Christensen J3; Zhang GJ*2,8,9 |
| 刊名 | Proc Natl Acad Sci U S A.
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| 出版日期 | 2017 |
| 卷号 | 114期号:29页码:7677-7682 |
| 关键词 | Pdx1 Desert Rodent Gene Conversion Homeobox Type 2 Diabetes |
| 英文摘要 | The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East. Sand rats survive with low caloric intake and when given high carbohydrate diets can become obese and develop symptoms of type II diabetes which, in extreme cases, leads to pancreatic failure and death. Previous studies have reported inability to detect the Pdx1 gene or protein in sand rats and other gerbils, leading to the hypothesis that absence of this insulin-regulating transcription factor may underlie diabetes susceptibility. Here we report sequencing of the sand rat genome and identification of an unusual, extensive and mutationally-biased GC-rich genomic domain encompassing many functionally essential genes, including the elusive Pdx1. The sequence of the Pdx1 homeobox gene has been grossly affected by extensive GC-biased mutation leading to the highest degree of divergence yet observed in the animal kingdom. In addition to molecular insights into restricted caloric intake in a desert species, the discovery of a chromosomal region subject to a greatly elevated mutation rate has widespread significance to evolution. |
| 语种 | 英语 |
| 资助机构 | This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. The Crick receives its core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. The Crick receives its core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. The Crick receives its core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. The Crick receives its core funding from Cancer Research UK, the UK Medical Research Council, and the Wellcome Trust. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12074]  |
| 专题 | 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_基因起源组 |
| 通讯作者 | peter.holland@zoo.ox.ac.uk, zhanggj@genomics.cn,richardscottheller@gmail.com |
| 作者单位 | 1.Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK 2.China National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China 3.Novo Nordisk, Måløv, Denmark 4.Molecular Genetics Unit, Okinawa Institute of Science and Technology Graduate University, 12 Onna, Okinawa 904-0495, Japan. 5.Francis Crick Institute, London, UK 6.Novo Nordisk Research Centre, Seattle, USA 7.School of Biological Sciences, Bangor University, UK 8.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, 17 Chinese Academy of Sciences, 650223, Kunming, China 9.Centre for Social Evolution, Department of Biology, Universitetsparken 15, University of 19 Copenhagen, DK-2100 Copenhagen, Denmark |
| 推荐引用方式 GB/T 7714 | Hargreaves AD[1],Zhou L,Li F,et al. Genome sequence of a diabetes-prone desert rodent reveals 1 a mutation hotspot around the ParaHox gene cluster[J]. Proc Natl Acad Sci U S A.,2017,114(29):7677-7682. |
| APA | Hargreaves AD[1].,Zhou L.,Li F.,Jansen PG.,Spiga E.,...&peter.holland@zoo.ox.ac.uk, zhanggj@genomics.cn,richardscottheller@gmail.com.(2017).Genome sequence of a diabetes-prone desert rodent reveals 1 a mutation hotspot around the ParaHox gene cluster.Proc Natl Acad Sci U S A.,114(29),7677-7682. |
| MLA | Hargreaves AD[1],et al."Genome sequence of a diabetes-prone desert rodent reveals 1 a mutation hotspot around the ParaHox gene cluster".Proc Natl Acad Sci U S A. 114.29(2017):7677-7682. |
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来源：昆明动物研究所
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