New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network
文献类型：期刊论文
| 作者 | Zhou KC1,2; Liu MX1,2; Cao Y*1; caoy@mail.kiz.ac.cn |
| 刊名 | Frontiers in Molecular Biosciences
 |
| 出版日期 | 2017 |
| 卷号 | 4期号:X页码:e46 |
| 关键词 | Cancer Mirna Function Oncogenes OncoGene–microrna–tumor Suppressor Gene Network Tumor Suppressor Genes |
| 英文摘要 | Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene-miRNA-TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene-miRNA-TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene-miRNA-TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer. |
| 语种 | 英语 |
| 资助机构 | This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617). ; This work was supported by the Natural Science Foundation of China (81272617). |
| 源URL | [http://159.226.149.26:8080/handle/152453/11949]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 通讯作者 | caoy@mail.kiz.ac.cn |
| 作者单位 | 1.Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China |
| 推荐引用方式 GB/T 7714 | Zhou KC,Liu MX,Cao Y*,et al. New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network[J]. Frontiers in Molecular Biosciences,2017,4(X):e46. |
| APA | Zhou KC,Liu MX,Cao Y*,&caoy@mail.kiz.ac.cn.(2017).New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.Frontiers in Molecular Biosciences,4(X),e46. |
| MLA | Zhou KC,et al."New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network".Frontiers in Molecular Biosciences 4.X(2017):e46. |
入库方式： OAI收割
来源：昆明动物研究所
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