Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta
文献类型：期刊论文
| 作者 | Chen ZY*1,2; Parkkonen L1; Carlson S1,2; Wei JK3; Dong JR3; Ma YY3; zuyue.chen@helsinki.fi |
| 刊名 | Neuroscience bulletin
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 关键词 | Prepulse Inhibition Superior Temporal Gyrus Local Field Potential |
| 英文摘要 | Prepulse inhibition (PPI) refers to a decreased response to a startling stimulus when another weaker stimulus precedes it. Most PPI studies have focused on the physiological startle reflex and fewer have reported the PPI of cortical responses. We recorded local field potentials (LFPs) in four monkeys and investigated whether the PPI of auditory cortical responses (alpha, beta, and gamma oscillations and evoked potentials) can be demonstrated in the caudolateral belt of the superior temporal gyrus (STGcb). We also investigated whether the presence of a conspecific, which draws attention away from the auditory stimuli, affects the PPI of auditory cortical responses. The PPI paradigm consisted of Pulse-only and Prepulse + Pulse trials that were presented randomly while the monkey was alone (ALONE) and while another monkey was present in the same room (ACCOMP). The LFPs to the Pulse were significantly suppressed by the Prepulse thus, demonstrating PPI of cortical responses in the STGcb. The PPI-related inhibition of the N1 amplitude of the evoked responses and cortical oscillations to the Pulse were not affected by the presence of a conspecific. In contrast, gamma oscillations and the amplitude of the N1 response to Pulse-only were suppressed in the ACCOMP condition compared to the ALONE condition. These findings demonstrate PPI in the monkey STGcb and suggest that the PPI of auditory cortical responses in the monkey STGcb is a pre-attentive inhibitory process that is independent of attentional modulation. |
| 语种 | 英语 |
| 资助机构 | This work was supported by the aivoAALTO Project of Aalto University, the Academy of Finland (a grant No. P273147, a Project No. T31116, and the International Program/China- Finland 2014-2016), and the National Natural Science Foundation of China (31271168). ; This work was supported by the aivoAALTO Project of Aalto University, the Academy of Finland (a grant No. P273147, a Project No. T31116, and the International Program/China- Finland 2014-2016), and the National Natural Science Foundation of China (31271168). ; This work was supported by the aivoAALTO Project of Aalto University, the Academy of Finland (a grant No. P273147, a Project No. T31116, and the International Program/China- Finland 2014-2016), and the National Natural Science Foundation of China (31271168). ; This work was supported by the aivoAALTO Project of Aalto University, the Academy of Finland (a grant No. P273147, a Project No. T31116, and the International Program/China- Finland 2014-2016), and the National Natural Science Foundation of China (31271168). |
| 源URL | [http://159.226.149.26:8080/handle/152453/12061]  |
| 专题 | 昆明动物研究所_认知障碍病理学 |
| 通讯作者 | zuyue.chen@helsinki.fi |
| 作者单位 | 1.Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, 00076 Espoo, Finland 2.Department of Physiology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland 3.Laboratory of Primate Neurosciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Chen ZY*,Parkkonen L,Carlson S,et al. Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta[J]. Neuroscience bulletin,2017,**(**):published online. |
| APA | Chen ZY*.,Parkkonen L.,Carlson S.,Wei JK.,Dong JR.,...&zuyue.chen@helsinki.fi.(2017).Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta.Neuroscience bulletin,**(**),published online. |
| MLA | Chen ZY*,et al."Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta".Neuroscience bulletin **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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