Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
文献类型：期刊论文
| 作者 | So HC*1,2; Chau CKL1; Yim SHY4; Sham PC5,6,7,8; Chiu WT3; Ho KS3; Lo CP3; hcso@cuhk.edu.hk |
| 刊名 | Nature Neuroscience
 |
| 出版日期 | 2017 |
| 卷号 | **期号:**页码:published online |
| 英文摘要 | Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence. Repositioning candidates for a number of disorders were also significantly enriched for known psychiatric medications or therapies considered in clinical trials. For example, candidates for schizophrenia were enriched for antipsychotics, while those for bipolar disorder were enriched for both antipsychotics and antidepressants. These findings provide support for the usefulness of GWAS data in guiding drug discovery. |
| 语种 | 英语 |
| 资助机构 | This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. |
| 源URL | [http://159.226.149.26:8080/handle/152453/12022]  |
| 专题 | 昆明动物研究所_其他 |
| 通讯作者 | hcso@cuhk.edu.hk |
| 作者单位 | 1.School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China. 2.KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Zoology Institute of Zoology and The Chinese University of Hong Kong, China 3.Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China 4.Univeristy of Exeter Medical School, Exeter, UK 5.Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong, China 6.Centre for Genomic Sciences, University of Hong Kong, Pokfulam, Hong Kong, China 7.State Key Laboratory for Cognitive and Brain Sciences, University of Hong Kong, Pokfulam, Hong Kong, China 8.Centre for Reproduction, Development and Growth, University of Hong Kong, Pokfulam, Hong Kong, China. |
| 推荐引用方式 GB/T 7714 | So HC*,Chau CKL,Yim SHY,et al. Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry[J]. Nature Neuroscience,2017,**(**):published online. |
| APA | So HC*.,Chau CKL.,Yim SHY.,Sham PC.,Chiu WT.,...&hcso@cuhk.edu.hk.(2017).Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry.Nature Neuroscience,**(**),published online. |
| MLA | So HC*,et al."Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry".Nature Neuroscience **.**(2017):published online. |
入库方式： OAI收割
来源：昆明动物研究所
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