Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships
文献类型：期刊论文
| 作者 | Chen, Si-Yue1,2,3; Geng, Chang-An1,2 ; Ma, Yun-Bao1,2; Huang, Xiao-Yan1,2; Yang, Xiao-Tong1,2,3; Su, Li-Hua1,2,3; He, Xiao-Feng1,2,3; Li, Tian-Ze1,2; Deng, Zhen-Tao1,2,3; Gao, Zhen1,2,3
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 27期号:15页码:3299-3306 |
| 关键词 | Gastrodia elata Polybenzyls Melatonin receptors Structure-activity relationships Docking study |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2019.06.008 |
| 通讯作者 | Chen, Ji-Jun(chenjj@mail.kib.ac.cn) |
| 英文摘要 | Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, nine polybenzyls (1-9), including six new ones (2-5, 7 and 9), were isolated from the EtOAc extract of G. elata. Five compounds 1, 3, 4, 6 and 8 were found to activate melatonin receptors. Especially, compound 1 showed agonistic effects on MT1 and MT2 receptors with EC50 values of 237 and 244 mu M. For better understanding their structure-activity relationships (SARs), ten polybenzyl analogs were further synthesized and assayed for their activities on melatonin receptors. Preliminary SARs study suggested that two para-hydroxy groups were the key pharmacophore for maintaining activity. Molecular docking simulations verified that compound 1 could strongly interact with MT2 receptor by bonding to Phe 118, Gly 121, His 208, Try 294 and Ala 297 residues. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000476649400009 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68129]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Chen, Ji-Jun |
| 作者单位 | 1.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Si-Yue,Geng, Chang-An,Ma, Yun-Bao,et al. Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2019,27(15):3299-3306. |
| APA | Chen, Si-Yue.,Geng, Chang-An.,Ma, Yun-Bao.,Huang, Xiao-Yan.,Yang, Xiao-Tong.,...&Chen, Ji-Jun.(2019).Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships.BIOORGANIC & MEDICINAL CHEMISTRY,27(15),3299-3306. |
| MLA | Chen, Si-Yue,et al."Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships".BIOORGANIC & MEDICINAL CHEMISTRY 27.15(2019):3299-3306. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。