Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii
文献类型：期刊论文
| 作者 | Xia, Fan4,5,7; Li, Wen-Yan1,4,6; Yang, Xing-Wei5,7 ; Yang, Jian1,6; Li, Xian2,3; Nian, Yin1,6; Xu, Gang5,7
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-07-19 |
| 卷号 | 21期号:14页码:5670-5674 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b01527 |
| 通讯作者 | Li, Xian(xianlikm@163.com) ; Nian, Yin(nianyin@mail.kiz.ac.cn) ; Xu, Gang(xugang008@mail.kib.ac.cn) |
| 英文摘要 | Salpratlactones A (1) and B (2), a pair of abietane cis-trans tautomers from Salvia prattii, were identified as the first naturally occurring agonists of T-type calcium channel (TTCC). Structurally, 1 and 2 were featured by unique 6/5 carbocyclic rings bearing a gamma-lactone ring through an exocyclic double bond. Moreover, both compounds and their mixture at 10 mu M potently and equally increased Ca(v)3.1 TTCC peak currents, and 1 had an EC50 value of 12.48 mu M. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000476957200062 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68187]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Xian; Nian, Yin; Xu, Gang |
| 作者单位 | 1.Chinese Acad Sci, Ion Channel Res & Drug Dev Ctr, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 6.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 7.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Fan,Li, Wen-Yan,Yang, Xing-Wei,et al. Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii[J]. ORGANIC LETTERS,2019,21(14):5670-5674. |
| APA | Xia, Fan.,Li, Wen-Yan.,Yang, Xing-Wei.,Yang, Jian.,Li, Xian.,...&Xu, Gang.(2019).Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii.ORGANIC LETTERS,21(14),5670-5674. |
| MLA | Xia, Fan,et al."Salpratlactones A and B: A Pair of cis-trans Tautomeric Abietanes as Ca(v)3.1 T-Type Calcium Channel Agonists from Salvia prattii".ORGANIC LETTERS 21.14(2019):5670-5674. |
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来源：昆明植物研究所
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