Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
文献类型：期刊论文
| 作者 | Chen, Keliang1; Chen, Chunmei1; Guo, Jieru1,2; Sun, Weiguang1; Liu, Junjun1; Yang, Jing3 ; Liu, Xiulan2; Wang, Jianping1; Luo, Zengwei1; Zhu, Hucheng1
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2019-08-01 |
| 卷号 | 164页码:236-242 |
| 关键词 | Guignardia mangiferae Spirocyclic meroterpenoids Anti-inflammatory Nuclear factor-kappa B (NF-kappa B) |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2019.05.018 |
| 通讯作者 | Zhu, Hucheng(zhuhucheng@hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | Mangiterpenes A-C and 2',3'-seco-manginoid C, four undescribed sesquiterpene/monoterpene-shikimate-conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A-C represent the first examples of sesquiterpene-shikimate-conjugated spirocyclic meroterpenoids, and 2',3'-seco-manginoid C features an unexpected 2',3'-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 mu M. It showed an anti-inflammatory effect by means of blocking in the NF-kappa B signaling pathway and decreasing the expression of inflammatory mediators. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000475996800027 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68226]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhu, Hucheng; Zhang, Yonghui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Keliang,Chen, Chunmei,Guo, Jieru,et al. Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae[J]. PHYTOCHEMISTRY,2019,164:236-242. |
| APA | Chen, Keliang.,Chen, Chunmei.,Guo, Jieru.,Sun, Weiguang.,Liu, Junjun.,...&Zhang, Yonghui.(2019).Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.PHYTOCHEMISTRY,164,236-242. |
| MLA | Chen, Keliang,et al."Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae".PHYTOCHEMISTRY 164(2019):236-242. |
入库方式： OAI收割
来源：昆明植物研究所
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