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Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin

文献类型：期刊论文

作者Zhu, Huifang1,3; Wang, Bin1,3; Kong, Lingmei3; An, Tao3; Li, Gentao2,3; Zhou, Hongyu3; Gong, Liang1,3; Zhao, Zhangxun1,3; Gong, Yaxiao3; Sun, Handong3
刊名CELL CHEMICAL BIOLOGY
出版日期2019-08-15
卷号26期号:8页码:1122-+
ISSN号2451-9448
DOI10.1016/j.chembiol.2019.04.003
通讯作者Puno, Pematenzin(punopematenzin@mail.kib.ac.cn) ; Li, Yan(liyanb@mail.kib.ac.cn)
英文摘要Natural killer (NK) cells play a crucial role in the surveillance of malignant cells. The engagement of NK group 2 member D (NKG2D) receptor with its ligands on target cells represents a promising therapeutic strategy against cancers. Here, we report that parvifoline AA (PAA), a natural ent-kaurane diterpenoid, markedly stimulates the expression of NKG2D ligands on hepatocellular carcinoma (HCC) cells, considerably enhancing their recognition and lysis by NK cells. We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells. Robust tumor growth inhibition by PAA dependent on NK cell activation was detected in vivo. Our data suggest Prxs-I/II as a promising cancer immune therapeutic target and provide a compelling rationale for further development of the inhibitor PAA as a sensitizer agent for NK cell-mediated HCC immunotherapy.
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000481604100009
源URL[http://ir.kib.ac.cn/handle/151853/68364]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Puno, Pematenzin; Li, Yan
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Huifang,Wang, Bin,Kong, Lingmei,et al. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin[J]. CELL CHEMICAL BIOLOGY,2019,26(8):1122-+.
APA Zhu, Huifang.,Wang, Bin.,Kong, Lingmei.,An, Tao.,Li, Gentao.,...&Li, Yan.(2019).Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.CELL CHEMICAL BIOLOGY,26(8),1122-+.
MLA Zhu, Huifang,et al."Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin".CELL CHEMICAL BIOLOGY 26.8(2019):1122-+.

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来源：昆明植物研究所

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