Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
文献类型：期刊论文
| 作者 | Qi, Changxing4; Zhou, Qun4; Gao, Weixi4; Liu, Mengting4; Chen, Chunmei4; Li, Xiao-Nian3; Lai, Yongji1; Zhou, Yuan4 ; Li, Dongyan2; Hu, Zhengxi4
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 165页码:8 |
| 关键词 | Aspergillus terreus Thom endophytic fungus 3,5-Dimethylorsellinic acid-based meroterpenoid Adducts Alzheimer's disease |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2019.05.014 |
| 通讯作者 | Li, Dongyan(lidongyan2016@sina.com) ; Hu, Zhengxi(hzx616@126.com) ; Zhu, Hucheng(zhuhucheng0@163.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | Spiroterreusnoids A-F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experimental electronic circular dichroism (ECD) measurements. Spiroterreusnoids A-F represent the first examples of adducts composed of 3,5-dimethylorsellinic acidbased meroterpenoids. It is noteworthy that spiroterreusnoids A-F possessing a spiro-dioxolane moiety exhibited potential abilities in inhibiting BACE1 (IC50 values ranging from 5.86 to 27.16 mu M) and AchE (IC50 values ranging from 22.18 to 32.51 mu M), while the other analogues without this fragment displayed no such activities. Taken together, spiroterreusnoids A-F represent the first multitargeted natural adducts that could inhibit BACE1 and AchE, and might provide a new template for the development of new anti-Alzheimer's disease drugs. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000482248900005 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68376]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Dongyan; Hu, Zhengxi; Zhu, Hucheng; Zhang, Yonghui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pharm, Wuhan, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Changxing,Zhou, Qun,Gao, Weixi,et al. Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom[J]. PHYTOCHEMISTRY,2019,165:8. |
| APA | Qi, Changxing.,Zhou, Qun.,Gao, Weixi.,Liu, Mengting.,Chen, Chunmei.,...&Zhang, Yonghui.(2019).Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom.PHYTOCHEMISTRY,165,8. |
| MLA | Qi, Changxing,et al."Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom".PHYTOCHEMISTRY 165(2019):8. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。