Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens
文献类型：期刊论文
| 作者 | Zang, Yi1; Gong, Yi-Hua1; Li, Xu-Wen3; Li, Xiao-Nian2; Liu, Jun-Jun1; Chen, Chun-Mei1; Zhou, Yuan1 ; Gu, Liang-Hu1; Luo, Zeng-Wei1; Wang, Jian-Ping1
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2019-09-21 |
| 卷号 | 6期号:18页码:3274-3281 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c9qo00820a |
| 通讯作者 | Sun, Wei-Guang(weiguang_s@hust.edu.cn) ; Zhu, Hu-Cheng(zhuhucheng@hust.edu.cn) ; Zhang, Yong-Hui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | Three pairs of enantiomers (+/-)-canescones A-C (1-3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3-5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000484960000014 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68626]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Sun, Wei-Guang; Zhu, Hu-Cheng; Zhang, Yong-Hui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zang, Yi,Gong, Yi-Hua,Li, Xu-Wen,et al. Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(18):3274-3281. |
| APA | Zang, Yi.,Gong, Yi-Hua.,Li, Xu-Wen.,Li, Xiao-Nian.,Liu, Jun-Jun.,...&Zhang, Yong-Hui.(2019).Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens.ORGANIC CHEMISTRY FRONTIERS,6(18),3274-3281. |
| MLA | Zang, Yi,et al."Canescones A-E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens".ORGANIC CHEMISTRY FRONTIERS 6.18(2019):3274-3281. |
入库方式： OAI收割
来源：昆明植物研究所
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