Three new C23 steroids from the leaves and stems of Nicandra physaloides
文献类型：期刊论文
| 作者 | Zhang, Ling1,2; Peng, Xingrong2; Zhao, Gaoting2; Xia, Jianjun1; Lu, Jing2; Zhou, Lin2; Wang, Kunmiao1; Li, Zhihua1; Qiu, Minghua2
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| 刊名 | STEROIDS
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 150页码:4 |
| 关键词 | Nicandra physaloides Solanaceae Withanolide C23 steroids |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2019.06.001 |
| 通讯作者 | Qiu, Minghua(mhchiu@mail.kib.ac.cn) |
| 英文摘要 | Nicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000486110300002 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/68677]  |
| 专题 | 中国科学院昆明植物研究所 |
| 通讯作者 | Qiu, Minghua |
| 作者单位 | 1.China Tobacco Yunnan Ind Co Ltd, R&D Ctr, Yunnan Key Lab Tobacco Chem, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ling,Peng, Xingrong,Zhao, Gaoting,et al. Three new C23 steroids from the leaves and stems of Nicandra physaloides[J]. STEROIDS,2019,150:4. |
| APA | Zhang, Ling.,Peng, Xingrong.,Zhao, Gaoting.,Xia, Jianjun.,Lu, Jing.,...&Qiu, Minghua.(2019).Three new C23 steroids from the leaves and stems of Nicandra physaloides.STEROIDS,150,4. |
| MLA | Zhang, Ling,et al."Three new C23 steroids from the leaves and stems of Nicandra physaloides".STEROIDS 150(2019):4. |
入库方式： OAI收割
来源：昆明植物研究所
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